Changes in seizure duration during acute course electroconvulsive therapy.
Changes in seizure duration during acute course electroconvulsive therapy.
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DOI：
10.1016/j.brs.2021.05.016
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发表时间：
2021-07
影响因子：
7.7
通讯作者：
Henry ME
中科院分区：
文献类型：
--
作者：
Luccarelli J;McCoy TH Jr;Seiner SJ;Henry ME
长期以来，癫痫发作持续时间一直被视为ECT治疗效果的潜在标志，人们担心短暂的癫痫发作可能在临床上无效。相对较小的研究已经记录了急性期ECT发作时间缩短的趋势，但来自大型队列的数据将有助于提供治疗期间发作持续时间变化的规范性数据。本研究在一个大型单中心队列中分析了年龄、性别、电痉挛剂量和治疗次数对急性电痉挛期间电痉挛持续时间的影响。对2000-2017年在一家大型独立精神病院接受第一疗程电痉挛治疗的成年患者进行单中心回顾性图表回顾。3648例患者符合纳入标准，接受32879例急性期ECT治疗。在急性过程中，平均电痉挛发作时间缩短，在前3次治疗中持续时间减少最多，但在整个急性过程中持续减少。年龄越大、ECT剂量越大、治疗次数越多与癫痫发作时间越短有关，而性别与癫痫发作时间无显著相关性。与不增加剂量相比，增加治疗剂量与更短的癫痫发作相关，接受最高累积剂量的患者也具有最短的累积癫痫发作时间。在接受急性ECT治疗的患者中，癫痫发作持续时间在治疗过程中减少，外加电荷的增加与癫痫发作时间缩短有关。
Seizure duration has long been measured as a potential marker of ECT treatment efficacy, with concern that short seizures may be clinically ineffective. Relatively small studies have documented a trend towards shorter seizures during acute course ECT, but data from large cohorts would help provide normative data on seizure duration changes during treatment. This study analyzes the effects of age, sex, ECT dose, and treatment number on the duration of electrographic seizures during acute course ECT in a large single-center cohort. A single-center retrospective chart review was conducted of adult patients receiving a first course of ECT from 2000-2017 at a large freestanding psychiatric hospital. 3,648 patients met inclusion criteria, receiving 32,879 acute course ECT treatments. There was a shortening of mean ECT seizure duration over the acute course, with the greatest decrease in duration over the first 3 treatments but continuing decreases over the entire acute course. Older age, higher ECT dose, and increasing treatment number were all associated with shorter seizures, while sex was not significantly associated. Increasing treatment dose was associated with shorter seizures relative to no dose increase, with those patients receiving the highest cumulative doses also having the shortest cumulative seizure time. Among patients undergoing acute-course ECT treatment, seizure duration decreased over the treatment course, and increases in applied electrical charge were associated with shorter seizures.
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影响因子：
158.5
作者：
SACKEIM, HA;PRUDIC, J;SETTEMBRINO, JM
通讯作者：
SETTEMBRINO, JM
影响因子：
11.9
作者：
Chung, KF
通讯作者：
Chung, KF
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作者：
Kimball, James N.;Rosenquist, Peter B.;McCall, Vaughn
通讯作者：
McCall, Vaughn
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2.5
作者：
Frey, R;Heiden, A;Kasper, S
通讯作者：
Kasper, S
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2.5
作者：
Rasimas, Joseph J.;Stevens, Susanna R.;Rasmussen, Keith G.
通讯作者：
Rasmussen, Keith G.