Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas.
Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas.
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间充质干细胞治疗恶性胶质瘤的现状和潜在挑战
DOI：
10.1186/s13287-018-0977-z
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发表时间：
2018-08-24
影响因子：
7.5
通讯作者：
Fu P
中科院分区：
文献类型：
--
作者：
Zhang Q;Xiang W;Yi DY;Xue BZ;Wen WW;Abdelmaksoud A;Xiong NX;Jiang XB;Zhao HY;Fu P
神经胶质瘤占原发性中枢神经系统肿瘤的30%以上，其特征是头痛，癫痫和视力模糊等症状。多形性胶质母细胞瘤是成人中最具侵袭性、恶性和致命性的脑肿瘤。即使采用手术、放疗和化疗的渐进式联合治疗，胶质瘤患者的预后仍然极差。相对于疗效不佳、技术发展缓慢的手术和放疗，靶向化疗以其新的作用机制成为该领域的研究热点，而且靶向治疗对大多数实体瘤都有很好的应用前景。干细胞（包括神经干细胞和间充质干细胞）的肿瘤嗜性能力提供了一种替代的治疗方法。因此，基于间充质干细胞的治疗是基于肿瘤选择能力，并且在过去几十年中被认为是有效的抗肿瘤选择。近年来，间充质干细胞治疗脑胶质瘤的基础研究越来越多，取得了复杂的结果，本文综述了间充质干细胞的生物学特性，以及间充质干细胞治疗脑胶质瘤的研究现状和面临的挑战。
Glioma, which accounts for more than 30% of primary central nervous system tumours, is characterised by symptoms such as headaches, epilepsy, and blurred vision. Glioblastoma multiforme is the most aggressive, malignant, and lethal brain tumour in adults. Even with progressive combination treatment with surgery, radiotherapy, and chemotherapy, the prognosis for glioma patients is still extremely poor. Compared with the poor outcome and slowly developing technologies for surgery and radiotherapy, the application of targeted chemotherapy with a new mechanism has become a research focus in this field.Moreover, targeted therapy is promising for most solid tumours. The tumour-tropic ability of stem cells, including neural stem cells and mesenchymal stem cells, provides an alternative therapeutic approach. Thus, mesenchymal stem cell-based therapy is based on a tumour-selective capacity and has been thought to be an effective anti-tumour option over the past decades. An increasing number of basic studies on mesenchymal stem cell-based therapy for gliomas has yielded complex outcomes.In this review, we summarise the biological characteristics of human mesenchymal stem cells, and the current status and potential challenges of mesenchymal stem cell-based therapy in patients with malignant gliomas.
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DOI：
10.1007/s00432-014-1642-2
发表时间：
2014-08-01
影响因子：
3.6
作者：
Guo, Ke-Tai;Fu, Peng;Schichor, Christian
通讯作者：
Schichor, Christian
长期非编码RNA参与神经干细胞生物学和脑病理生理学的最新进展。
影响因子：
4
作者：
Antoniou D;Stergiopoulos A;Politis PK
通讯作者：
Politis PK
影响因子：
3.7
作者：
Dasari VR;Velpula KK;Kaur K;Fassett D;Klopfenstein JD;Dinh DH;Gujrati M;Rao JS
通讯作者：
Rao JS
DOI：
10.1073/pnas.97.23.12846
发表时间：
2000-11-07
影响因子：
11.1
作者：
Aboody, KS;Brown, A;Snyder, EY
通讯作者：
Snyder, EY
影响因子：
3.3
作者：
Gunnarsson, Salina;Bexell, Daniel;Bengzon, Johan
通讯作者：
Bengzon, Johan