Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer.
Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer.
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DOI：
10.1186/1476-4598-9-152
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发表时间：
2010-06-17
期刊：
影响因子：
37.3
通讯作者：
Thijssen VL
中科院分区：
文献类型：
--
作者：
Dingemans AM;van den Boogaart V;Vosse BA;van Suylen RJ;Griffioen AW;Thijssen VL
选择复发风险高的早期非小细胞肺癌患者是必要的，以选择将从辅助治疗策略中获益的患者。我们对68例早期非小细胞肺癌患者的冷冻原发肿瘤进行了回顾性研究，评估了整合素表达谱的预后价值。回顾性分析68例早期非小细胞肺癌患者的冷冻原发肿瘤，随访至少10年。从所有肿瘤组织中分离RNA并逆转录成cDNA。使用qPCR生成包括整联蛋白α 1、2、3、4、5、6、7、11和V以及整联蛋白β 1、3、4、5、6和8的mRNA表达谱。整合素α 5、β 1和β 3的表达水平可预测早期NSCLC患者的总生存期和无病生存期。整合素表达与淋巴结转移无关。组织学亚型之间的比较揭示了鳞状细胞癌的独特整合素特征，而腺癌和大细胞癌的特征基本相同。整合素在NSCLC中的表达对于肿瘤的发展和行为是重要的，并且影响患者的生存。确定整合素的表达谱可能作为一种工具，在预测个别患者的预后。
Selection of early stage non-small cell lung cancer patients with a high risk of recurrence is warranted in order to select patients who will benefit from adjuvant treatment strategies. We evaluated the prognostic value of integrin expression profiles in a retrospective study on frozen primary tumors of 68 patients with early stage non-small cell lung cancer. A retrospective study was performed on frozen primary tumors of 68 early stage non-small cell lung cancer patients with a follow up of at least 10 years. From all tumor tissues, RNA was isolated and reverse transcribed into cDNA. qPCR was used to generate mRNA expression profiles including integrins alpha1, 2, 3, 4, 5, 6, 7, 11, and V as well as integrins beta1, 3, 4, 5, 6, and 8. The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage NSCLC patients. There was no association between integrin expression and lymph node metastases. Comparison between the histological subtypes revealed a distinct integrin signature for squamous cell carcinoma while the profiles of adenocarcinoma and large cell carcinoma were largely the same. Integrin expression in NSCLC is important for the development and behavior of the tumor and influences the survival of the patient. Determining the integrin expression profile might serve as a tool in predicting the prognosis of individual patients.
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影响因子：
45.3
作者：
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作者：
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