Antihypertensive Use and the Risk of Alzheimer's Disease and Related Dementias among Older Adults in the USA.
Antihypertensive Use and the Risk of Alzheimer's Disease and Related Dementias among Older Adults in the USA.
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DOI：
10.1007/s40266-022-00981-8
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发表时间：
2022-11
期刊：
影响因子：
2.8
通讯作者：
Shi, Lu
中科院分区：
文献类型：
--
作者：
Pan, Xi;Zhang, Donglan;Heo, Ji Haeng;Park, Chanhyun;Li, Gang;Dengler-Crish, Christine M.;Li, Yan;Gu, Yian;Young, Henry N.;Lavender, Devin L.;Shi, Lu
关于不同类别的抗高血压药物以及阿尔茨海默病和相关痴呆症（ADRD）风险的流行病学证据不确定且有限。本研究探讨了老年高血压患者中抗高血压药物使用（包括治疗类型和抗高血压药物类别）与ADRD诊断之间的关系。进行了一项回顾性横断面研究，涉及539名年龄在65岁及以上的人，他们使用抗高血压药物，并从2013-2018年医疗支出小组调查（MEPS）数据中选择ADRD诊断。预测因素是治疗类型（单药治疗或多药治疗）和使用Multum Lexicon治疗分类定义的抗高血压药物类别（以钙通道阻滞剂[CCB]作为参考组）。采用加权logistic回归分析评估治疗类型和抗高血压药物使用类别与ADRD诊断的关系，调整社会人口学特征和健康状况。我们发现单药治疗和多药治疗在ADRD诊断的几率上没有显著差异。在单药治疗中，使用血管紧张素转换酶抑制剂（ACEI）的患者发生AD的几率显著低于使用CCB的患者（OR=0.36，95%CI = 0.13 - 0.99）。这项研究的结果表明，需要循证药物治疗来管理成年后期的高血压，并需要进一步研究抗高血压药物（特别是ACEI）对老年高血压患者AD发展的保护作用机制。
Epidemiological evidence on different classes of antihypertensives and risks of Alzheimer’s disease and related dementias (ADRD) is inconclusive and limited. This study examined the association between antihypertensive use (including therapy type and antihypertensive class) and ADRD diagnoses among older adults with hypertension. A retrospective, cross-sectional study was conducted, involving 539 individuals aged 65 and older who used antihypertensives and had ADRD diagnosis selected from 2013–2018 Medical Expenditure Panel Survey (MEPS) data. The predictors were therapy type (monotherapy or polytherapy) and class of antihypertensives defined using Multum Lexicon therapeutic classification (with calcium channel blockers [CCBs] as the reference group). Weighted logistic regression was used to assess the relationships of therapy type and class of antihypertensives use with ADRD diagnosis, adjusting for sociodemographic characteristics and health status. We found no significant difference between monotherapy and polytherapy on the odds of ADRD diagnosis. As to monotherapy, those who used angiotensin-converting enzyme inhibitors (ACEIs) had significantly lower odds of developing AD compared to those who used CCBs (OR=0.36, 95% CI = 0.13 – 0.99). Findings of the study suggest the need for evidence-based drug therapy to manage hypertension in later adulthood and warrant further investigation into the mechanism underlying the protective effect of antihypertensives, particularly ACEIs, against the development of AD among older adults with hypertension.
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影响因子：
14
作者：
Johnson, Michael L.;Parikh, Niraj;Morgan, Robert O.
通讯作者：
Morgan, Robert O.
DOI：
10.1161/hypertensionaha.112.195511
发表时间：
2012-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carnevale D;Mascio G;D'Andrea I;Fardella V;Bell RD;Branchi I;Pallante F;Zlokovic B;Yan SS;Lembo G
通讯作者：
Lembo G
影响因子：
7
作者：
Mougias, Antonis A.;Politis, Antonis;Mavreas, Venetsanos G.
通讯作者：
Mavreas, Venetsanos G.
影响因子：
14
作者：
通讯作者：
--
影响因子：
8.3
作者：
An, Jaejin;Luong, Tiffany;Reynolds, Kristi
通讯作者：
Reynolds, Kristi