MicroRNAs as regulators of airborne pollution-induced lung inflammation and carcinogenesis
MicroRNAs as regulators of airborne pollution-induced lung inflammation and carcinogenesis
复制标题
MicroRNA 作为空气污染引起的肺部炎症和癌变的调节剂
DOI：
10.1007/s00204-015-1462-4
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
W. C. Cho
中科院分区：
文献类型：
--
作者：
F. Li;J. Yang;X. Liu;W. C. Cho
肺部炎症和肺癌的发病率日益增加，以及由于接触空气中污染物（例如微粒物质和香烟烟雾）而使原有的慢性肺病恶化，正在成为世界上一个主要的公共卫生问题。然而，暴露于这些空气污染的肺损伤的确切机制尚未完全阐明。然而，越来越多的证据表明，microRNAs （miRNAs）可能在空气介质诱导的肺部炎症和癌变的调节中发挥独特的作用。由于表观遗传修饰具有遗传性和可逆性，这可能为mirna与环境污染相关肺部疾病的关系提供新的见解。这篇综述的目的是更新我们现有的关于空气污染物改变肺部miRNA谱的机制的知识，特别是香烟烟雾和空气中的颗粒物，以及miRNA在肺部炎症和肺癌发生中的潜在生物学作用，以及对这些环境压力源的潜在遗传易感性的调节。
The increasing incidence of pulmonary inflammation and lung cancer, as well as exacerbation of pre-existing chronic lung diseases by exposure to airborne pollutants, e.g., particulate matter and cigarette smoke, is becoming a major public health concern in the world. However, the exact mechanisms of pulmonary injury from exposure to these airborne insults have not been fully elucidated. Nevertheless, accumulating evidence suggests that microRNAs (miRNAs) may play a unique role in the regulation of airborne agent-induced lung inflammation and carcinogenesis. Since epigenetic modifications are heritable and reversible, this may provide a new insight into the relationship of miRNAs and environmental pollution-related lung disorders. The aim of this review was to update our existing knowledge regarding the mechanisms by which airborne pollutants altering miRNA profiles in the lung, specifically for cigarette smoke and airborne particulate matter, and the potential biological roles of miRNAs in the initiation of pulmonary inflammation and lung cancer, as well as the regulation of underlying genetic susceptibility to these environmental stressors.
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DOI：
10.1146/annurev.pathol.4.110807.092222
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
--
作者：
Lee YS;Dutta A
通讯作者：
Dutta A
影响因子：
8.4
作者：
A. Izzotti;M. Bagnasco;C. Cartiglia;M. Longobardi;R. Balansky;A. Merello;R. Lubet;S. De Flora
通讯作者：
A. Izzotti;M. Bagnasco;C. Cartiglia;M. Longobardi;R. Balansky;A. Merello;R. Lubet;S. De Flora
DOI：
10.1186/1476-069x-10-45
发表时间：
2011-05-21
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Wilker EH;Alexeeff SE;Suh H;Vokonas PS;Baccarelli A;Schwartz J
通讯作者：
Schwartz J
影响因子：
--
作者：
Wong IC;Ng YK;Lui VW
通讯作者：
Lui VW
影响因子：
4.8
作者：
Gross, Thomas J.;Powers, Linda S.;Monick, Martha M.
通讯作者：
Monick, Martha M.