Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air pollution.
Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air pollution.
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DOI：
10.5732/cjc.014.10093
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发表时间：
2014-10
影响因子：
--
通讯作者：
Lui VW
中科院分区：
文献类型：
--
作者：
Wong IC;Ng YK;Lui VW
室外空气污染最近被世界卫生组织（WHO）列为I类人类致癌物。来自地球仪的累积证据表明，污染的空气与肺癌、头颈癌和鼻咽癌的风险增加有关，所有这些癌症都会影响上呼吸消化道。重要的是，这些癌症以前与吸烟有关。在这篇文章中，我们回顾了空气污染对DNA的遗传毒性和致突变作用的流行病学和实验证据，据称这是癌症发展的关键机制。亚洲上呼吸消化道癌症的惊人增长表明，政府有必要将努力和研究集中在减少空气污染、促进清洁能源和调查空气污染对人类的致癌影响上。
Outdoor air pollution has been recently classified as a class I human carcinogen by the World Health Organization (WHO). Cumulative evidence from across the globe shows that polluted air is associated with increased risk of lung, head and neck, and nasopharyngeal cancers—all of which affect the upper aerodigestive tract. Importantly, these cancers have been previously linked to smoking. In this article, we review epidemiologic and experimental evidence of the genotoxic and mutagenic effects of air pollution on DNA, purportedly a key mechanism for cancer development. The alarming increase in cancers of the upper aerodigestive tract in Asia suggests a need to focus government efforts and research on reducing air pollution, promoting clean energy, and investigating the carcinogenic effects of air pollution on humans.
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影响因子：
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作者：
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通讯作者：
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DOI：
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