Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis.
Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis.
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DOI：
10.1590/2359-3997000000313
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发表时间：
2017-12
影响因子：
1.7
通讯作者：
Campennì, Alfredo
中科院分区：
文献类型：
--
作者：
Trovato, Maria;Giuffrida, Giuseppe;Seminara, Antonino;Fogliani, Simone;Cavallari, Vittorio;Ruggeri, Rosaria Maddalena;Campennì, Alfredo
甲状腺乳头状癌（PTC）是最常见的甲状腺癌类型。相反，原发性甲状腺淋巴瘤（PTL）是一种罕见的疾病，占所有甲状腺恶性肿瘤的2%至5%。尽管有几例PTC和PTL都出现在桥本甲状腺炎（HT）的背景下，HT患者中两种肿瘤的共存是非常罕见的。在此，我们报告一位66岁女性长期结节性高血压接受替代治疗的病例，她的右前侧颈部快速无痛性肿大。甲状腺超声检查显示右叶低回声结节生长增加，大小为32 × 20 mm。进行了甲状腺全切除术，组织学检查显示在华丽HT背景下存在弥漫性大B细胞淋巴瘤（DLBCL）。此外，还发现了一个单灶性乳头状微小癌，经典的变体（7 mm，pT1aNxMx）。然后，患者接受了PTL化疗，但未按照指南接受microPTC放射性碘消融治疗。手术后两年，患者没有任何恶性肿瘤复发的证据。这一罕见病例强调了监测结节性病变HT患者的重要性，特别是如果他们有长期疾病。此外，PTL应考虑鉴别诊断老年HT患者谁提出了突然甲状腺肿大。
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck. Thyroid ultrasonography demonstrated increased growth of a hypoechoic nodule in the right lobe measuring 32 × 20 mm. A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid HT. Moreover, a unifocal papillary microcarcinoma, classical variant (7 mm, pT1aNxMx), was discovered. The patient was then treated with chemotherapy for the PTL, but she did not undergo radioactive iodine ablation treatment for the microPTC as per guidelines. Two years after surgery, the patient had no evidence of recurrence of either malignancy. This rare case highlights the importance of monitoring HT patients with nodular lesions, especially if they have long-standing disease. In addition, PTL should be considered for differential diagnosis in elder HT patients who present with sudden thyroid enlargement.
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DOI：
10.1002/hed.23917
发表时间：
2015-09-01
影响因子：
2.9
作者：
Xie, Shumin;Liu, Wei;Ren, Jihao
通讯作者：
Ren, Jihao
影响因子：
3.9
作者：
Azizi G;Keller JM;Lewis M;Piper K;Puett D;Rivenbark KM;Malchoff CD
通讯作者：
Malchoff CD
DOI：
10.3803/enm.2013.28.4.341
发表时间：
2013-12
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
--
作者：
Nam YJ;Kim BH;Lee SK;Jeon YK;Kim SS;Jung WJ;Kahng DH;Kim IJ
通讯作者：
Kim IJ
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
3.4
作者：
Moshynska, O. V.;Saxena, A.
通讯作者：
Saxena, A.