Analysis of nasal air conditioning in subjects with unilateral cleft lip nasal deformity.
Analysis of nasal air conditioning in subjects with unilateral cleft lip nasal deformity.
复制标题
单侧唇裂鼻畸形患者鼻空调效果分析。
DOI：
10.1016/j.resp.2021.103694
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发表时间：
2021-09
影响因子：
2.3
通讯作者：
Frank-Ito DO
中科院分区：
文献类型：
--
作者：
Li H;Martin HL;Marcus JR;Frank-Ito DO
本研究使用计算流体动力学（CFD）建模评估单侧唇裂鼻畸形（uCLND）对鼻通道加热和加湿吸入环境空气的能力的影响。在10名uCLND患者和7名正常解剖结构的患者中模拟静息吸气时的鼻腔空气调节。通过鼻粘膜的整体热量和水分传递在非裂隙侧比裂隙侧显著更大（对于热量和水分通量，p=0.02）。单侧中位数和四分位距（IQR）的热通量（W/m2）为190.3（IQR 59.9）的非裂侧，160.9（IQR 105.0）的裂侧，和170.7（IQR 87.8）的正常受试者。水分通量（mg/（s·m2））分别为357.4（IQR 112.9）、298.7（IQR 200.3）和320.8（IQR 173.0）。uCLND裂侧SAHF 50与正常对照组比较，除前区外，差异均有统计学意义（P <0.05）。然而，uCLND受试者的空调能力通常与正常受试者相当。
This study evaluates the impact of unilateral cleft lip nasal deformity (uCLND) on the ability of the nasal passages to warm and humidify inspired environmental air using computational fluid dynamics (CFD) modeling. Nasal air conditioning was simulated at resting inspiration in ten individuals with uCLND and seven individuals with normal anatomy. The overall heat and water transfer through nasal mucosa was significantly greater (p=0.02 for both heat and moisture fluxes) on the non-cleft side than on the cleft side. Unilateral median and interquartile range (IQR) for heat flux (W/m2) was 190.3 (IQR 59.9) on the non-cleft side, 160.9 (IQR 105.0) on the cleft side, and 170.7 (IQR 87.8) for normal subjects. For moisture flux (mg/(s·m2), they were 357.4 (IQR 112.9), 298.7 (IQR 200.3) and 320.8 (IQR 173.0), respectively. Significant differences of SAHF50 between cleft side of uCLND and normal existed except for anterior region. Nevertheless, air conditioning ability in subjects with uCLND was generally comparable to that of normal subjects.
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