Transient trimethylaminuria related to menstruation.
Transient trimethylaminuria related to menstruation.
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DOI：
10.1186/1471-2350-8-2
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发表时间：
2007-01-27
影响因子：
--
通讯作者：
Yamazaki, Hiroshi
中科院分区：
文献类型：
--
作者：
Shimizu, Makiko;Cashman, John R.;Yamazaki, Hiroshi
三甲基胺尿症，或鱼臭综合征，包括由于身体分泌物导致的过量恶臭的三甲胺引起的短暂或轻微的恶臭。在此，我们描述的数据支持的建议，月经可以是一个额外的因素，导致短暂的三甲基氨基尿症的自我报告的受试者患有恶臭，甚至在健康妇女窝藏功能活性黄素含单加氧酶3（FMO 3）。FMO 3代谢能力（将三甲胺转化为三甲胺N-氧化物）定义为尿中三甲胺N-氧化物与总三甲胺的比值。自我报告的病例（A）是失活Arg 500 stop FMO 3的纯合子，显示FMO 3的代谢能力降低（即，~10%未受影响的代谢能力）。对于常见[Glu 158 Lys; Glu 308 Gly] FMO 3多态性纯合的病例（B），FMO 3的代谢能力几乎为~ 90%，除了月经前后几天显示代谢能力< 40%。相比之下，三名健康对照受试者（其具有[Glu 158 Lys; Glu 308 Gly] FMO 3杂合多态性或野生FMO 3纯合多态性）显示正常（> 90%）代谢能力，然而，在月经前后的日子，FMO 3代谢能力降低至约60- 70%。总之，这些结果表明，异常FMO 3能力是由月经引起的，特别是在纯合形式存在轻度遗传变异如[Glu 158 Lys; Glu 308 Gly]的情况下，这些变异导致FMO 3功能降低。
Trimethylaminuria, or fish odor syndrome, includes a transient or mild malodor caused by an excessive amount of malodorous trimethylamine as a result of body secretions. Herein, we describe data to support the proposal that menses can be an additional factor causing transient trimethylaminuria in self-reported subjects suffering from malodor and even in healthy women harboring functionally active flavin-containing monooxygenase 3 (FMO3). FMO3 metabolic capacity (conversion of trimethylamine to trimethylamine N-oxide) was defined as the urinary ratio of trimethylamine N-oxide to total trimethylamine. Self-reported Case (A) that was homozygous for inactive Arg500stop FMO3, showed decreased metabolic capacity of FMO3 (i.e., ~10% the unaffected metabolic capacity) during 120 days of observation. For Case (B) that was homozygous for common [Glu158Lys; Glu308Gly] FMO3 polymorphisms, metabolic capacity of FMO3 was almost ~90%, except for a few days surrounding menstruation showing < 40% metabolic capacity. In comparison, three healthy control subjects that harbored heterozygous polymorphisms for [Glu158Lys; Glu308Gly] FMO3 or homozygous for wild FMO3 showed normal (> 90%) metabolic capacity, however, on days around menstruation the FMO3 metabolic capacity was decreased to ~60–70%. Together, these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function.
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影响因子：
3.9
作者：
Hernandez, D;Addou, S;Phillips, IR
通讯作者：
Phillips, IR
影响因子：
--
作者：
Shimizu, Makiko;Cashman, John R.;Yamazaki, Hiroshi
通讯作者：
Yamazaki, Hiroshi
影响因子：
6.1
作者：
Yamazaki, H;Fujieda, M;Kamataki, T
通讯作者：
Kamataki, T
影响因子：
3.8
作者：
Yamazaki, Hiroshi;Fujita, Haruka;Shimizu, Makiko
通讯作者：
Shimizu, Makiko