Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development.
Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development.
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探索早期发展研究中的空气污染、邻里剥夺和自闭症谱系障碍。
DOI：
10.1097/ee9.0000000000000067
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Daniels,JulieL
中科院分区：
文献类型：
--
作者：
McGuinn,LauraA;Windham,GayleC;Messer,LynneC;Di,Qian;Schwartz,Joel;Croen,LisaA;Moody,EricJ;Rappold,AnaG;Richardson,DavidB;Neas,LucasM;Gammon,MarilieD;Schieve,LauraA;Daniels,JulieL
背景：为了研究邻里剥夺是否会改变生命早期空气污染暴露与自闭症谱系障碍（ASD）之间的关系，我们使用了一项多地点病例对照研究的资源，即“早期发展研究”。方法：选取2003-2006年出生的确诊ASD患儿674例；对照是855名随机抽样的儿童，他们出生在同一时期，与病例居住在同一地理区域。空气污染的评估是通过道路距离和怀孕期间和生命第一年接触< 2.5µm （PM 2.5）的颗粒物来进行的。为了描述邻里剥夺，基于8个人口普查区社会经济地位相关参数创建了一个指数。连续指数被分为三个等级，分别代表低、中、高剥夺。采用Logistic回归估计比值比（ORs）和相应的95%置信区间（ci）。结果：邻里剥夺改变了第一年pm2.5暴露与ASD之间的关系（相互作用P = 0.08），对于生活在重度（OR= 2.42, 95% CI= 1.20, 4.86）而不是中度（OR= 1.21, 95% CI= 0.67, 2.17）或重度（OR= 1.46, 95% CI= 0.80, 2.65）邻里剥夺的儿童来说，这种关系更强。在怀孕期间，没有观察到道路接近或暴露导致加性或乘性偏离。结论：这些结果提供了一年内邻里剥夺和PM 2.5暴露与ASD相关的相互作用的暗示证据。
Background:To examine whether neighborhood deprivation modifies the association between early life air pollution exposure and autism spectrum disorder (ASD), we used resources from a multisite case–control study, the Study to Explore Early Development.Methods:Cases were 674 children with confirmed ASD born in 2003–2006; controls were 855 randomly sampled children born during the same time period and residents of the same geographic areas as cases. Air pollution was assessed by roadway proximity and particulate matter< 2.5 µm (PM 2.5) exposure during pregnancy and first year of life. To characterize neighborhood deprivation, an index was created based on eight census tract-level socioeconomic status-related parameters. The continuous index was categorized into tertiles, representing low, moderate, and high deprivation. Logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs).Results:Neighborhood deprivation modified (P for interaction= 0.08) the association between PM 2.5 exposure during the first year of life and ASD, with a stronger association for those living in high (OR= 2.42, 95% CI= 1.20, 4.86) rather than moderate (OR= 1.21, 95% CI= 0.67, 2.17) or low (OR= 1.46, 95% CI= 0.80, 2.65) deprivation neighborhoods. Departure from additivity or multiplicativity was not observed for roadway proximity or exposures during pregnancy.Conclusion:These results provide suggestive evidence of interaction between neighborhood deprivation and PM 2.5 exposure during the first year of life in association with ASD.
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DOI：
10.1056/nejmoa1307491
发表时间：
2014-03-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Stoner R;Chow ML;Boyle MP;Sunkin SM;Mouton PR;Roy S;Wynshaw-Boris A;Colamarino SA;Lein ES;Courchesne E
通讯作者：
Courchesne E
影响因子：
10.4
作者：
Zeger SL;Thomas D;Dominici F;Samet JM;Schwartz J;Dockery D;Cohen A
通讯作者：
Cohen A
影响因子：
3.8
作者：
Steptoe, A;Feldman, PJ
通讯作者：
Feldman, PJ
纽约市地区社会经济贫困、二氧化氮暴露和足月出生体重。
影响因子：
8.3
作者：
Shmool,JessieLC;Bobb,JenniferF;Ito,Kazuhiko;Elston,Beth;Savitz,DavidA;Ross,Zev;Matte,ThomasD;Johnson,Sarah;Dominici,Francesca;Clougherty,JaneE
通讯作者：
Clougherty,JaneE
影响因子：
11.8
作者：
Kingsley SL;Eliot MN;Whitsel EA;Huang YT;Kelsey KT;Marsit CJ;Wellenius GA
通讯作者：
Wellenius GA