Nationwide incidence of central retinal artery occlusion in Japan: an exploratory descriptive study using the National Database of Health Insurance Claims (2011-2015).
Nationwide incidence of central retinal artery occlusion in Japan: an exploratory descriptive study using the National Database of Health Insurance Claims (2011-2015).
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DOI：
10.1136/bmjopen-2020-041104
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发表时间：
2020-09-24
期刊：
影响因子：
2.9
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
--
作者：
Kido A;Tamura H;Ikeda HO;Miyake M;Hiragi S;Tsujikawa A
需要视网膜中央动脉阻塞（CRAO）发病率的最新证据来支持开发孤儿药的新治疗方法。然而，关于老龄化或老年人群中CRAO发生率的最新信息有限。我们的目的是调查全国流行病学和临床特征的CRAO在日本，使用全国范围内的健康保险索赔数据。我们分析了日本国家健康保险索赔和特定健康检查数据库（NDB）抽样数据集中的16069762份索赔数据，该数据库是全国范围内的1.27亿日本人的健康保险索赔数据库。使用国际疾病分类第10版诊断代码H34.1鉴定CRAO。根据WHO的标准年龄结构人群，计算CRAO的粗发病率和年龄标准化发病率。日本CRAO的粗发病率为5.84（95% CI，5.71 - 5.97）/100 000人-年。在性别相关的发病率方面，男性比女性高1.40倍（6.85（95% CI，6.65 ~ 7.06）vs 4.88（95% CI，4.71 ~ 5.05），p<0.001）。年龄标准化发病率为2.53（95% CI，2.29 - 2.76）/100 000人-年。日本CRAO的粗发病率高于其他国家，如以前报告的，反映了日本作为一个超老龄社会的人口结构。这些发现有助于制定适当的医疗保健政策，以解决随着人口老龄化而增加的CRAO发病率。
The latest evidence in the incidence of central retinal artery occlusion (CRAO) is needed to support the development of novel treatments as orphan drugs. However, up-to-date information on the incidence of CRAO in the ageing or aged population is limited. We aimed to investigate the nationwide epidemiological and clinical characteristics of CRAO in Japan, using nationwide health insurance claims data. We analysed a total of 16 069 762 claims data in the sampling dataset of the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), which is the nationwide health insurance claims database of 127 million whole Japanese individuals. CRAO was identified using the International Classification of Diseases 10th edition diagnostic code H34.1. The crude incidence rates and age-standardised incidence rates of CRAO, according to the standard age-structure population of the WHO, were calculated. The crude incidence rate of CRAO in Japan was 5.84 (95% CI, 5.71 to 5.97) per 100 000 person-years. With respect to the sex-related incidence, the rate was higher 1.40 times in men than in women (6.85 (95% CI, 6.65 to 7.06) vs 4.88 (95% CI, 4.71 to 5.05), p<0.001). The age-standardised incidence rate was 2.53 (95% CI, 2.29 to 2.76) per 100 000 person-years. The crude incidence rate of CRAO was higher in Japan than in other countries, as reported previously, reflecting the Japanese population structure as a super-aged society. These findings can be helpful for the development of appropriate healthcare policies to address the increasing incidence of CRAO with the ageing population.
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影响因子：
13.7
作者：
Schumacher, Martin;Schmidt, Dieter;Feltgen, Nicolas
通讯作者：
Feltgen, Nicolas
影响因子：
4.4
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影响因子：
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通讯作者：
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影响因子：
4.4
作者：
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