Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women.
Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women.
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赞比亚女性生殖器血吸虫病与宫颈阴道微生物群和性传播感染的关系。
DOI：
10.1093/ofid/ofab438
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Bustinduy AL
中科院分区：
文献类型：
--
作者：
Sturt AS;Webb EL;Himschoot L;Phiri CR;Mapani J;Mudenda M;Kjetland EF;Mweene T;Levecke B;van Dam GJ;Corstjens PLAM;Ayles H;Hayes RJ;van Lieshout L;Hansingo I;Francis SC;Cools P;Bustinduy AL
宫颈阴道微生物区系，包括性传播感染(STI)，在女性生殖器血吸虫病(FGS)中还没有得到很好的描述。女性(18-31岁，性活跃，未怀孕)被邀请参加2018年1月至8月HPTN 071(PopART)人口队列的最终后续行动。我们用定量聚合酶链式反应(QPCR)检测了宫颈阴道菌群中的关键菌种(卷曲乳杆菌、伊氏乳杆菌、阴道加德纳菌、阴道阿托波菌和念珠菌)和性传播感染(沙眼衣原体、淋球菌、阴道毛滴虫和生殖支原体)。我们评估了微生物区系和STI的存在和浓度与FGS(在3个生殖器标本中的任何一个中检测到血吸虫DNA)的相关性。有无FGS的受试者(n=30)和无FGS的受试者(n=158)的宫颈阴道菌的存在和浓度没有差别。阴道毛滴虫感染的比例高于阴性妇女(P=0.08)，进一步分析表明，阴道毛滴虫在≥2血吸虫qPCR阳性生殖器标本的妇女中的感染率(50.0%，8/16)高于FGS阴性妇女(21.5%，34/158；P=0.01)。我们发现了阴道毛滴虫和FGS之间存在联系的微弱证据，而在FGS感染负担较高的女性中，这种联系更强。需要对寄生虫之间潜在的相互作用进行更多的研究，特别是关于艾滋病毒-1的脆弱性。
The cervicovaginal microbiota, including sexually transmitted infections (STIs), have not been well described in female genital schistosomiasis (FGS). Women (aged 18–31, sexually active, nonpregnant) were invited to participate at the final follow-up of the HPTN 071 (PopART) Population Cohort in January–August 2018. We measured key species of the cervicovaginal microbiota (Lactobacillus crispatus, L. iners, Gardnerella vaginalis, Atopobium vaginae, and Candida) and STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) using quantitative PCR (qPCR). We evaluated associations of the microbiota and STI presence and concentration with FGS (qPCR-detected Schistosoma DNA in any of 3 genital specimens). The presence and concentration of key cervicovaginal species did not differ between participants with (n = 30) or without FGS (n = 158). A higher proportion of participants with FGS had T. vaginalis compared with FGS-negative women (P = .08), with further analysis showing that T. vaginalis was more prevalent among women with ≥2 Schistosoma qPCR-positive genital specimens (50.0%, 8/16) than among FGS-negative women (21.5%, 34/158; P = .01). We found weak evidence of an association between the presence of T. vaginalis and FGS, with a stronger association in women with a higher-burden FGS infection. Additional research is needed on potential between-parasite interactions, especially regarding HIV-1 vulnerability.
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影响因子：
3.7
作者：
Galappaththi-Arachchige HN;Holmen S;Koukounari A;Kleppa E;Pillay P;Sebitloane M;Ndhlovu P;van Lieshout L;Vennervald BJ;Gundersen SG;Taylor M;Kjetland EF
通讯作者：
Kjetland EF
阴道毛滴虫：流行病学、临床和治疗问题的回顾。
影响因子：
3.7
作者：
Kissinger P
通讯作者：
Kissinger P
DOI：
10.4269/ajtmh.2011.10-0585
发表时间：
2011-03-01
影响因子：
3.3
作者：
Downs, Jennifer A.;Mguta, Charles;Fitzgerald, Daniel W.
通讯作者：
Fitzgerald, Daniel W.
影响因子：
3.3
作者：
Gadoth, Adva;Mvumbi, Gisele;Rinnoin, Anne W.
通讯作者：
Rinnoin, Anne W.
影响因子：
3.1
作者：
Jarosik, GP;Land, CB;Mercer, T
通讯作者：
Mercer, T