Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea.
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea.
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DOI：
10.5056/jnm.2013.19.3.344
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发表时间：
2013-07
影响因子：
3.4
通讯作者：
Jung HC
中科院分区：
文献类型：
--
作者：
Kim JY;Kim N;Seo PJ;Lee JW;Kim MS;Kim SE;Jo SY;Lee DH;Jung HC
睡眠障碍和情绪障碍通常与胃食管反流病（GERD）有关。本研究的目的是评价糜烂性反流病（ERD）和非糜烂性反流病（NERD）患者的GERD症状和紊乱，并比较韩国对照组、ERD和NERD患者的睡眠功能障碍、抑郁情绪、焦虑和生活质量（QOL）。韩国受试者在2010年至2012年期间入组，分为3组;对照组无症状且内镜检查结果正常，ERD组有糜烂性食管炎，NERD组每周有1次以上烧心或反酸发作，质子泵抑制剂阳性反应，内镜检查结果正常。问卷包括GERD症状、GERD影响量表（GIS）和日间病理性嗜睡（埃普沃思嗜睡量表）、睡眠功能障碍（匹兹堡睡眠质量指数，PSQI）、抑郁和焦虑（医院焦虑和抑郁量表，HADS）和生活质量（WHO生活质量量表缩写版，WHOQOL-BREF）。共入组217例受试者，如下所示：对照组（n = 70）、ERD组（n = 70）和NERD组（n = 77）。NERD组的GIS症状影响评分（9.2 ± 0.4）高于ERD组（6.5 ± 0.3）（P < 0.001）。GERD组睡眠障碍发生率高于对照组（PSQI评分[P = 0.021]）。HAD焦虑分量表NERD组（7.0 ± 0.5）分，ERD组（6.2 ± 0.7）分，均高于对照组（4.3 ± 0.7）分，差异有统计学意义（P = 0.002）。NERD组和ERD组的WHOQOL-BREF评分分别为（54.9 ± 2.3）和（57.8 ± 2.4）分，均显著低于对照组（63.8 ± 2.4）分（分别为P = 0.002和P = 0.014）。 在韩国NERD患者比ERD患者遭受更多的症状和障碍。GERD患者睡眠障碍、焦虑情绪明显增高，生活质量下降，NERD患者尤为明显，提示这些因素可能影响NERD的严重程度。
Sleep disturbances and emotional dysfunction are commonly associated with gastroeophageal reflux disease (GERD). The aims of this study were to evaluate GERD symptoms and disturbance in erosive reflux disease (ERD) and nonerosive reflux disease (NERD) patients, and to compare sleep dysfunction, depressive mood, anxiety and quality of life (QOL) among the control, ERD and NERD patients in Korea. The Korean subjects were enrolled between 2010 and 2012, classified into 3 groups; the control group with no symptom and normal endoscopic findings, the ERD group with erosive esophagitis and the NERD group with more than one episode of heartburn or acid regurgitation per week, positive response to proton pump inhibitor, and normal endoscopic findings. Questionnaire included GERD symptoms, GERD impact scale (GIS) and daytime pathological sleepiness (Epworth sleepiness scale), sleep dysfunction (Pittsburgh sleep quality index, PSQI), depression and anxiety (Hospital anxiety and depression scale, HADS) and QOL (WHO quality of life scale abbreviated version, WHOQOL-BREF). A total of 217 subjects were enrolled as follows; control (n = 70), ERD (n = 70) and NERD (n = 77). Impact of symptom of GIS score was higher in the NERD (9.2 ± 0.4) than in the ERD (6.5 ± 0.3) group (P < 0.001). Sleep dysfunctions were more frequent in GERD than the control group (PSQI score [P = 0.021]). Anxiety subscale of HAD score was higher in NERD (7.0 ± 0.5, P = 0.002) and ERD (6.2 ± 0.7, P = 0.004) groups than control (4.3 ± 0.7) group. WHOQOL-BREF scores in NERD (54.9 ± 2.3) and ERD (57.8 ± 2.4) groups were significantly lower than those in the control group (63.8 ± 2.4) (P = 0.002; P = 0.014, respectively). The patients with NERD than ERD suffered more from the symptoms and disturbance in Korea. Sleep dysfunction and anxiety mood were higher and QOL was decreased in GERD, especially in NERD, suggesting that those factors might affect the severity of NERD.
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