Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation.
Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation.
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DOI：
10.3390/molecules27041149
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发表时间：
2022-02-09
期刊：
影响因子：
--
通讯作者：
Zakaria ZA
中科院分区：
文献类型：
--
作者：
Shamsudin NF;Ahmed QU;Mahmood S;Ali Shah SA;Khatib A;Mukhtar S;Alsharif MA;Parveen H;Zakaria ZA
根据世界卫生组织发布的最新报告，细菌对已知和广泛可用的抗菌药物的耐药性已成为一个重大而严重的全球健康问题，也是有效治疗多重耐药病原微生物相关感染的严峻挑战。因此，各种策略已被精心策划，以有效地治愈与多重耐药细菌相关的严重并发症。一些方法涉及延缓细菌中的生物膜形成和多药耐药泵，以及发现表现出不同作用机制的新的抗菌剂。在这方面，天然产物即生物碱、萜类、甾体、蒽醌、黄酮、皂苷、单宁等，由于其多方面的药理作用，已被建议用于解决多药耐药菌株。其中，黄酮类化合物，也称为多酚化合物，由于其具有延缓多种病原微生物（包括多重耐药细菌）生长的趋势，已被广泛评价其抗菌特性。C5、C7、C3′和C4′的羟基化以及C6的香叶基化或异戊烯基化已被广泛研究以增加类黄酮的细菌抑制。另一方面，据报道，C3′和C5的甲氧基化会降低黄酮类化合物的抗菌作用。因此，黄酮类化合物的抗菌活性的最新信息进行了总结，特别注意这一广泛的天然化合物的构效关系，发现安全和有效的抗菌剂作为天然产物。
According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of biofilm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, flavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrug-resistant bacteria. The hydroxylation of C5, C7, C3′, and C4′; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of flavonoids. On the other hand, methoxylation at C3′ and C5 has been reported to decrease flavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products.
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DOI：
10.3390/molecules22040608
发表时间：
2017-04-10
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Echeverría J;Opazo J;Mendoza L;Urzúa A;Wilkens M
通讯作者：
Wilkens M
与驱动类黄酮抗菌活性的微生物蛋白相互作用。
影响因子：
5.4
作者：
Donadio G;Mensitieri F;Santoro V;Parisi V;Bellone ML;De Tommasi N;Izzo V;Dal Piaz F
通讯作者：
Dal Piaz F
影响因子：
4.2
作者：
Chisti MJ;Harris JB;Carroll RW;Shahunja KM;Shahid ASMSB;Moschovis PP;Schenkel SR;Hasibur Rahman ASMM;Shahrin L;Faruk T;Kabir F;Ahmed D;Ahmed T
通讯作者：
Ahmed T
影响因子：
2.6
作者：
Abreu, Ana Cristina;Serra, Sofia C.;Simoes, Manuel
通讯作者：
Simoes, Manuel
影响因子：
3.5
作者：
Avila, Hugo Pereira;Albino Smania, Elza de Fatima;Junior, Artur Smania
通讯作者：
Junior, Artur Smania