Evaluation of novel stimulus waveforms for deep brain stimulation.
Evaluation of novel stimulus waveforms for deep brain stimulation.
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DOI：
10.1088/1741-2560/7/6/066008
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发表时间：
2010-12
影响因子：
4
通讯作者：
McIntyre CC
中科院分区：
文献类型：
--
作者：
Foutz TJ;McIntyre CC
脑深部电刺激（DBS）是一种治疗多种神经系统疾病的成熟疗法。从历史上看，DBS和其他神经刺激技术依赖于矩形刺激波形对神经系统施加影响。最近的研究表明，非矩形波形可能比传统的矩形脉冲有优势。因此，我们使用详细的计算机模型将一系列电荷平衡的双相波形与矩形、指数、三角形、高斯和正弦刺激脉冲形状进行比较。我们探索了这些波形在细胞内和细胞外刺激下的神经激活能量。在细胞外刺激的背景下，我们比较了它们对传代神经元和投射神经元轴突纤维的影响。最后，我们评估了通过临床DBS电极传递波形的影响，而不是理论点源。我们的研究结果表明，与标准的100 μs矩形脉冲（刺激50%的轴突的能量成本分别为48 nJ和133 nJ）相比，1 ms中心三角形脉冲的DBS可以减少64%的能量消耗，与最节能的矩形脉冲（1.25 ms持续时间）相比，可以减少10%的能量消耗。反过来，当在临床DBS应用中使用适当设计的非矩形脉冲时，可能会有可测量的节能，因此需要进一步的实验研究。
Deep brain stimulation (DBS) is an established therapy for the treatment of a wide range of neurological disorders. Historically, DBS and other neurostimulation technologies have relied on rectangular stimulation waveforms to impose their effects on the nervous system. Recent work has suggested that non-rectangular waveforms may have advantages over the traditional rectangular pulse. Therefore, we used detailed computer models to compare a range of charge-balanced biphasic waveforms with rectangular, exponential, triangular, Gaussian, and sinusoidal stimulus pulse shapes. We explored the neural activation energy of these waveforms in both intracellular and extracellular stimulation. In the context of extracellular stimulation, we compared their effects on both axonal fibers of passage and projection neurons. Finally, we evaluated the impact of delivering the waveforms through a clinical DBS electrode, as opposed to a theoretical point source. Our results suggest that DBS with a 1 ms centered-triangular pulse can decrease energy consumption by 64 % when compared to the standard 100 μs rectangular pulse (energy cost of 48 nJ and 133 nJ, respectively, to stimulate 50 % of a distributed population of axons) and can decrease energy consumption by 10 % when compared to the most energy efficient rectangular pulse (1.25 ms duration). In turn, there may be measureable energy savings when using appropriately designed non-rectangular pulses in clinical DBS applications, thereby warranting further experimental investigation.
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影响因子：
8.6
作者：
Anheim, Mathieu;Fraix, Valerie;Pollak, Pierre
通讯作者：
Pollak, Pierre
影响因子：
4.1
作者：
MORTIMER, JT;SHEALY, CN;WHEELER, C
通讯作者：
WHEELER, C
影响因子：
56.9
作者：
LILLY, JC;HUGHES, JR;GALKIN, TW
通讯作者：
GALKIN, TW
影响因子：
2
作者：
Nowak, LG;Bullier, J
通讯作者：
Bullier, J
影响因子：
4.1
作者：
Ondo, William G.;Meilak, Catherine;Vuong, Kevin D.
通讯作者：
Vuong, Kevin D.