Wavelength-dependent penetration depth of near infrared radiation into cartilage.
Wavelength-dependent penetration depth of near infrared radiation into cartilage.
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DOI：
10.1039/c4an01987c
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发表时间：
2015-04-07
期刊：
影响因子：
--
通讯作者：
Pleshko N
中科院分区：
文献类型：
--
作者：
Padalkar MV;Pleshko N
关节软骨是一种透明软骨，排列在关节关节的软骨下骨上。近红外（NIR）光谱已成为评估软骨病理学的一种无损方式。然而，缺乏对近红外辐射穿透软骨深度的研究。人体软骨的平均厚度约为1-3毫米，随着骨关节炎的进展，软骨会变得更薄。为了确保收集的光谱数据仅限于感兴趣的组织，即本例中的软骨，而不是来自下面的软骨下骨，有必要确定近红外辐射在不同波长（频率）区域的穿透深度。在当前的研究中，我们确定了穿透深度在整个 NIR 频率范围 (4000-10000 cm-1) 中如何变化。 NIR 光谱是从不同厚度（0.5 毫米至 5 毫米）的软骨样品中收集的，无论其下方是否放置聚苯乙烯。收集聚苯乙烯的单独近红外光谱作为参考。研究发现，穿透深度在 4000-5100 cm-1 范围内变化范围为 ∼1 mm 至 2 mm，在 5100-7000 cm-1 范围内变化为 ∼3 mm，在 7000-9000 cm-1 频率范围内变化为 ∼5 mm。这些发现表明，仅评估没有软骨下骨贡献的软骨的最佳 NIR 区域在 4000-7000 cm-1 之间。
Articular cartilage is a hyaline cartilage that lines the subchondral bone in a diarthrodial joint. Near infrared (NIR) spectroscopy has been emerging as a nondestructive modality for evaluation of cartilage pathology. However, studies of the depth of penetration of NIR radiation into cartilage are lacking. The average thickness of human cartilage is about 1-3 mm, and it becomes even thinner as OA progresses. To ensure that the spectral data collected is restricted to the tissue of interest i.e. cartilage in this case, and not from the underlying subchondral bone, it is necessary to determine the depth of penetration of NIR radiation in different wavelength (frequency) regions. In the current study we establish how the depth of penetration varies throughout the NIR frequency range (4000-10000 cm-1). NIR spectra were collected from cartilage samples of different thicknesses (0.5 mm to 5 mm) with and without polystyrene placed underneath. A separate NIR spectrum of polystyrene was collected as a reference. It was found that the depth of penetration varied from ∼1 mm to 2 mm in the 4000-5100 cm-1 range, to ∼3 mm in the 5100-7000 cm-1 range, and to ∼5 mm in the 7000-9000 cm-1 frequency range. These findings suggest that the best NIR region to evaluate cartilage only with no subchondral bone contribution is between 4000-7000 cm-1.
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影响因子：
3.5
作者：
McGoverin, Cushla M.;Lewis, Karl;Pleshko, Nancy
通讯作者：
Pleshko, Nancy
DOI：
10.1088/0143-0815/12/4/005
发表时间：
1991-11-01
期刊：
CLINICAL PHYSICS AND PHYSIOLOGICAL MEASUREMENT
影响因子：
--
作者：
FARIS, F;THORNILEY, M;SPENCER, A
通讯作者：
SPENCER, A
影响因子：
2.3
作者：
Neogi, Tuhina;Zhang, Yuqing
通讯作者：
Zhang, Yuqing
影响因子：
7
作者：
Afara, I.;Prasadam, I.;Oloyede, A.
通讯作者：
Oloyede, A.
DOI：
10.1097/00003086-200110001-00004
发表时间：
2001-10-01
影响因子：
4.2
作者：
Poole, AR;Kojima, T;Laverty, S
通讯作者：
Laverty, S