Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis.
Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis.
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DOI：
10.1002/evl3.227
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发表时间：
2021-06
影响因子：
5
通讯作者：
Butlin RK
中科院分区：
文献类型：
--
作者：
Koch EL;Morales HE;Larsson J;Westram AM;Faria R;Lemmon AR;Lemmon EM;Johannesson K;Butlin RK
长期以来，染色体倒置因其在局部适应中的作用而被公认。通过抑制杂合子个体的重组，它们可以维持共适应的基因复合体，并保护它们免受基因流的同质化影响。然而，为了充分理解它们对局部适应的重要性，我们需要知道它们在不同选择下对表型的影响。对此，海螺Littorina saxatilis提供了一个理想的研究体系。适应波浪作用和捕食螃蟹的不同生态型在潮间带海岸附近发生，两者之间存在基因流动。在这里，我们使用从生态型之间杂交获得的F2个体来测试基因组区域与区分蟹/浪适应生态型的特征之间的关联，包括大小、形状、壳厚度和行为。我们表明，这些性状中的大多数都受到两个先前检测到的倒位区域的影响，这两个倒位区域在生态类型之间存在差异。因此，我们对生态型快速和重复形成的一个重要潜在机制有了更好的理解：作用于倒位的发散选择。我们还发现，一些倒位导致了不止一个性状，这表明它们可能包含几个参与适应的基因座，这与倒位内抑制重组有助于在存在基因流的情况下促进分化的假设一致。
Chromosomal inversions have long been recognized for their role in local adaptation. By suppressing recombination in heterozygous individuals, they can maintain coadapted gene complexes and protect them from homogenizing effects of gene flow. However, to fully understand their importance for local adaptation we need to know their influence on phenotypes under divergent selection. For this, the marine snail Littorina saxatilis provides an ideal study system. Divergent ecotypes adapted to wave action and crab predation occur in close proximity on intertidal shores with gene flow between them. Here, we used F2 individuals obtained from crosses between the ecotypes to test for associations between genomic regions and traits distinguishing the Crab‐/Wave‐adapted ecotypes including size, shape, shell thickness, and behavior. We show that most of these traits are influenced by two previously detected inversion regions that are divergent between ecotypes. We thus gain a better understanding of one important underlying mechanism responsible for the rapid and repeated formation of ecotypes: divergent selection acting on inversions. We also found that some inversions contributed to more than one trait suggesting that they may contain several loci involved in adaptation, consistent with the hypothesis that suppression of recombination within inversions facilitates differentiation in the presence of gene flow.
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DOI：
10.1111/evo.12329
发表时间：
2014-04
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Butlin RK;Saura M;Charrier G;Jackson B;André C;Caballero A;Coyne JA;Galindo J;Grahame JW;Hollander J;Kemppainen P;Martínez-Fernández M;Panova M;Quesada H;Johannesson K;Rolán-Alvarez E
通讯作者：
Rolán-Alvarez E
影响因子：
4.9
作者：
Coughlan, Jennifer M.;Willis, John H.
通讯作者：
Willis, John H.
影响因子：
3.7
作者：
Ayala D;Ullastres A;González J
通讯作者：
González J
影响因子：
3.3
作者：
Charlesworth, Brian;Barton, Nicholas H.
通讯作者：
Barton, Nicholas H.
影响因子：
2.1
作者：
Durmaz E;Benson C;Kapun M;Schmidt P;Flatt T
通讯作者：
Flatt T