Interaction between XRCC1 Polymorphisms and Intake of Long-Term Stored Rice in the Risk of Esophageal Squamous Cell Carcinoma: A Case-Control Study
Interaction between XRCC1 Polymorphisms and Intake of Long-Term Stored Rice in the Risk of Esophageal Squamous Cell Carcinoma: A Case-Control Study
复制标题
XRCC1 多态性与长期储存大米摄入量之间的相互作用与食管鳞状细胞癌风险的关系：病例对照研究
DOI：
10.3967/0895-3988.2011.03.010
复制
发表时间：
2011-06
影响因子：
3.5
通讯作者：
Fu ChaoWei
中科院分区：
文献类型：
--
作者：
Xu Biao;Xue HengChuan;Yu HongJie;Wang JianMing;Fu ChaoWei
摘要目的探讨X线修复交叉互补组1基因（XRCC 1）3个常见单核苷酸多态性与生活方式因素在中国人食管鳞状细胞癌（ESCC）发病中的作用及其可能的交互作用。方法采用病例对照研究方法，对江苏省扬中县432例病例和915例对照进行研究。受试者进行了采访，由训练有素的采访人员使用结构化问卷，其中包括人口统计学和生活方式的问题。采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）分析方法分析XRCC 1基因型。非条件Logistic回归分析用于计算ESCC与XRCC 1多态性和生活方式相关因素的关联的校正比值比（aOR）和95%置信区间（CI）。结果饮用河水和饮酒史均与食管癌发病风险显著相关，aOR分别为4.20（95%CI：2.90-6.07）和2.03（95%CI：1.43-2.89）。对于女性，饮用河水的相应比值比为8.37（95%CI：5.09-13.75），长期储存大米摄入的相应比值比为12.78（95%CI：2.69-60.69）。在调整XRCC 1 G28152 A多态性潜在混杂因素后，GA和AA基因型受试者ESCC风险增加（aOR：1.21，95%CI：0.93-1.56），且长期储藏大米的摄入量与XRCC 1 G28152 A多态性之间存在正交互作用（P =0.009）。结论饮用河水、长期储存大米和饮酒等生活方式相关因素以及XRCC 1 G28152 A基因多态性可能是中国人食管癌的危险因素，且XRCC 1 G28152 A基因多态性改变了长期储存大米摄入对中国人食管癌危险性的影响。
Abstract Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene ( XRCC1 ) and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma (ESCC) in China. Methods A population-based case-control study of 432 cases and 915 controls was conducted in Yangzhong County, Jiangsu Province, China. Subjects were interviewed by trained interviewers using a structured questionnaire that included questions on demographics and life style. XRCC1 genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) assay. Unconditional logistic regression analysis was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for associations of ESCC with XRCC1 polymorphisms and lifestyle-related factors. Results Both the drinking of river water and alcohol intake history were significantly associated [SW1]with an increased risk of ESCC among men with aORs of 4.20 (95% CI: 2.90-6.07) and 2.03 (95% CI: 1.43-2.89), respectively. For women, the corresponding odds ratios were 8.37 (95% CI: 5.09-13.75) for river water drinking and 12.78 (95% CI: 2.69-60.69) for long-term stored rice intake. After the XRCC1 G28152A polymorphism was adjusted for potential confounders, subjects with GA and AA genotypes had an increased risk for ESCC (aOR: 1.21, 95% CI: 0.93-1.56), compared with subjects with a GG genotype, and a positive multiplicative interaction between intake of long-term stored rice and the XRCC1 G28152A polymorphism was observed ( P =0.009). Conclusions Our findings suggest that both lifestyle-related factors, including drinking river water, long-term stored rice and alcohol intake, and the XRCC1 G28152A polymorphism were possible risk factors for ESCC, and that the XRCC1 G28152A polymorphism modified the effect of long-term stored rice intake on the risk of ESCC among Chinese people.
登录
查看更多内容
影响因子：
4
作者：
John C. Layke;P. Lopez
通讯作者：
John C. Layke;P. Lopez
DOI：
--
发表时间：
2005-05
期刊：
--
影响因子：
--
作者：
王芹
通讯作者：
王芹
影响因子：
4.2
作者：
Gao W;Romkes M;Zhong S;Nukui T;Persad RA;Smith PJ;Branch R;Keohavong P
通讯作者：
Keohavong P
影响因子：
--
作者：
Shi Xi-shun
通讯作者：
Shi Xi-shun
影响因子：
3.8
作者：
Loizidou, Maria A.;Michael, Thalia;Hadjisavvas, Andreas
通讯作者：
Hadjisavvas, Andreas