malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication.
malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication.
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DOI：
10.1371/journal.pmed.1002455
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发表时间：
2017-11
期刊：
影响因子：
15.8
通讯作者：
malERA Refresh Consultative Panel on Tools for Malaria Elimination
中科院分区：
文献类型：
--
作者：
malERA Refresh Consultative Panel on Tools for Malaria Elimination
自进入世纪以来，可用于预防、治疗和控制疟疾的产品和战略的范围和有效性显著扩大，包括诊断、药物、疫苗和病媒控制方面的进展。这些进展再次将消灭疟疾提上议程。然而，很明显，即使有今天的手段，控制和消灭疟疾在许多情况下仍然是一项艰巨的挑战。因此，必须更有效地利用现有资源，并开发有可能实现这些目标的新产品和新方法。本文件考虑了实现和维持消除疟疾的工具（包括现有工具和可能需要的其他工具）。需要新的诊断方法来指导治疗和检测传播潜力;需要新的药物和疫苗来克服现有的耐药性，预防临床和严重疾病，并阻断传播和防止复发;需要新的病媒控制措施来克服杀虫剂耐药性，更有力地阻断传播。同样重要的是，为不同的环境制定将新的和现有的方法结合起来的战略，以在持续传播和接受的地区最大限度地延长其寿命和有效性。对于最近已经实现局部消除的地区，了解需要采取哪些措施来维持消除是必要的，以防止反弹和重新建立传播。随着越来越多的国家走向消除，这一点变得越来越重要。大卫Kaslow和他的同事们审查了在消除和根除疟疾中重新评估诊断、药物、疫苗和病媒控制方面的进展，并提出了一个研究议程。
Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination. David Kaslow and colleagues examine the progress in reasearch for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication and propose a research agenda.
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DOI：
10.1016/s1473-3099(16)30409-1
发表时间：
2017-03
期刊：
The Lancet. Infectious diseases
影响因子：
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DOI：
10.1073/pnas.1510801112
发表时间：
2015-09-29
影响因子：
11.1
作者：
Andriessen, Rob;Snetselaar, Janneke;Farenhorst, Marit
通讯作者：
Farenhorst, Marit
影响因子：
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影响因子：
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作者：
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