Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient.

Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient.
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DOI:
10.1186/1475-2875-5-69
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发表时间:
2006-08-04
期刊:
影响因子:
3
通讯作者:
Krause PJ
Krause PJ
中科院分区:
医学3区
文献类型:
--
作者:
Clark IA;Budd AC;Hsue G;Haymore BR;Joyce AJ;Thorner R;Krause PJ

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The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved. Giemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were examined to ascertain the distribution of parasitized erythrocytes within the vascular lumen. No evidence of sequestration was observed. This first report on the vascular location of B. microti in human tissue suggests that severe multi-organ failure due to babesiosis is independent of sequestration of parasitized erythrocytes. A similar pathogenesis may also cause multi-organ failure in other intraerythrocytic protozoal infections, including falciparum malaria.
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