Properties of sodium-driven bacterial flagellar motor: A two-state model approach

Properties of sodium-driven bacterial flagellar motor: A two-state model approach
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钠驱动细菌鞭毛运动的特性:两种状态模型方法

DOI:
10.1142/s0217984914502704
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发表时间:
2013-12
影响因子:
1.9
通讯作者:
Yunxin Zhang
Yunxin Zhang
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
Yunxin Zhang

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细菌鞭毛马达(Bacterial flagellar motor,BFM)是一种离子驱动的分子机器,它驱动鞭毛丝旋转,使细菌能够在粘性溶液中游动。了解其机制是生物物理学的一个挑战。在前人模型的基础上,受马达蛋白描述思想的启发,提出了一个双态模型。同时,根据相应的实验数据,给出了BFM膜电压与环境pH值的数学关系,以及膜内外钠离子浓度的关系。因此,通过将扭矩-速度关系的理论结果与最近的实验数据拟合获得的模型参数值,可以获得细菌鞭毛马达在任何pH值和任何外部钠浓度下的许多生物物理性质,包括旋转速度、失速扭矩(即BFM产生的扭矩)、旋转分散性和旋转随机性。本文首先对单定子无刷电机进行了分析,然后简要介绍了多定子无刷电机的特性。
Bacterial flagellar motor (BFM) is one of the ion-driven molecular machines, which drives the rotation of flagellar filaments and enable bacteria to swim in viscous solutions. Understanding its mechanism is one challenge in biophysics. Based on previous models and inspired by the idea used in description of motor proteins, in this study one two-state model is provided. Meanwhile, according to corresponding experimental data, mathematical relationship between BFM membrane voltage and pH value of the environment, and relationship between internal and external sodium concentrations are given. Therefore, with model parameter values obtained by fitting theoretical results of torque-speed relation to recent experimental data, many biophysical properties of bacterial flagellar motor can be obtained for any pH values and any external sodium concentrations, including the rotation speed, stall torque (i.e. the torque generated by BFM), rotation dispersion, and rotation randomness. In this study, the single-stator BFM will be firstly analyzed, and then properties of multiple-stator BFM are addressed briefly.
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