Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers.
Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers.
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环状RNA调节与癌症相关的信号通路，是人类癌症潜在的诊断生物标志物。
DOI：
10.1186/s12935-021-02017-4
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发表时间：
2021-06-23
影响因子：
5.8
通讯作者：
Fu J
中科院分区：
文献类型：
--
作者：
Garlapati P;Ling J;Chiao PJ;Fu J
环状RNA（circRNA）是在包括癌症在内的各种病理过程中具有重要作用的RNA。在使用高通量RNA测序后，发现许多circRNA在各种癌细胞系中差异表达，并通过调节特定基因的表达来调节细胞信号通路。了解它们在这些途径中的作用以及它们在哪些癌症中被发现，可以为确定癌症的诊断和预后生物标志物和治疗靶点奠定基础。本文将讨论在不同癌症中发现的circRNA以及它们用于上调或下调某些细胞成分的机制。
Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer cell lines and regulate cell signaling pathways by modulating particular gene expressions. Understanding their role in these pathways and what cancers they are found in can set the stage for identifying diagnostic and prognostic biomarkers and therapeutic targets of cancer. This paper will discuss which circRNAs are found in different cancers and what mechanisms they use to upregulate or downregulate certain cellular components.
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