MAGUKs, synaptic development, and synaptic plasticity.
MAGUKs, synaptic development, and synaptic plasticity.
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DOI：
10.1177/1073858410386384
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Petralia RS
中科院分区：
文献类型：
--
作者：
Zheng CY;Seabold GK;Horak M;Petralia RS
MAGUK是一种蛋白质，在含有受体、黏附蛋白和各种信号分子的表面复合体中充当关键支架。这些复合体在多细胞动物出现之前就进化了，并在细胞间的相互交流中发挥了关键作用。一个主要的例子是神经元突触，它包含几个突触前和突触后MAGUK，包括PSD-95，SAP102，SAP97，PSD-93，CAASK和MAGIS。在这里，它们在突触发育和后来的突触可塑性事件中都发挥着作用。在发育过程中，MAGUK通过与其他支架蛋白如Shank和肌动蛋白细胞骨架结合来帮助组织突触后密度。它们影响谷氨酸受体和其他受体的聚集，这些联系随着发育而改变。MAGUK参与长期的增强和抑制(例如，通过它们被激酶的磷酸化和与MAGUK相关的其他蛋白质的磷酸化)。重要的是，突触的发育和功能取决于存在的Maguk的种类。例如，SAP102表现出高流动性，存在于突触发育的早期。后来，SAP102的大部分被PSD-95取代，PSD-95是一种更稳定的突触Maguk；这与突触成熟所特有的谷氨酸受体类型的变化有关。
MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication. A major example of this is the neuronal synapse, which contains several presynaptic and postsynaptic MAGUKs including PSD-95, SAP102, SAP97, PSD-93, CASK, and MAGIs. Here, they play roles in both synaptic development and in later synaptic plasticity events. During development, MAGUKs help to organize the postsynaptic density via associations with other scaffolding proteins, such as Shank, and the actin cytoskeleton. They affect the clustering of glutamate receptors and other receptors, and these associations change with development. MAGUKs are involved in long-term potentiation and depression (e.g., via their phosphorylation by kinases and phosphorylation of other proteins associated with MAGUKs). Importantly, synapse development and function are dependent on the kind of MAGUK present. For example, SAP102 shows high mobility and is present in early synaptic development. Later, much of SAP102 is replaced by PSD-95, a more stable synaptic MAGUK; this is associated with changes in glutamate receptor types that are characteristic of synaptic maturation.
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影响因子：
16.2
作者：
Frost, Nicholas A.;Shroff, Hari;Kong, Huihui;Betzig, Eric;Blanpied, Thomas A.
通讯作者：
Blanpied, Thomas A.
DOI：
10.1523/jneurosci.4992-08.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bartos JA;Ulrich JD;Li H;Beazely MA;Chen Y;Macdonald JF;Hell JW
通讯作者：
Hell JW
DOI：
10.1073/pnas.0811025106
发表时间：
2008-12-30
影响因子：
11.1
作者：
Elias, G. M.;Elias, L. A. B.;Nicoll, R. A.
通讯作者：
Nicoll, R. A.
影响因子：
16.2
作者：
Barria, A;Malinow, R
通讯作者：
Malinow, R
影响因子：
3.4
作者：
de Mendoza A;Suga H;Ruiz-Trillo I
通讯作者：
Ruiz-Trillo I