Stimulation-induced entrainment of hippocampal network activity: Identifying optimal input frequencies.
Stimulation-induced entrainment of hippocampal network activity: Identifying optimal input frequencies.
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海马体包含丰富的振荡活动，节律性电流的连续起伏限制了它整合输入的能力。在联想学习期间，海马体必须整合来自一系列来源的输入，这些来源携带关于事件及其发生的背景的信息。在这种情况下，发送者和接收者之间的活动在时间上的协调很可能是成功沟通的关键。以往的研究表明，在联想学习任务中，外侧内嗅皮层(LEC)和海马区CA1区之间的节律性活动的协调与学习的开始密切相关。我们的目的是检查LEC在特定频率范围内的节律输入是否足以增强CA1下游活动的时间协调。在乌拉坦麻醉的大鼠中，我们在LEC的整个长度上施加细胞外低强度交流电刺激。使用这种方法，我们的目标是在不同的频率范围(从1.2 5到55 赫兹)对LEC中正在进行的神经元活动进行相位偏置。在35和50 赫兹的节律性刺激下，CA1区神经元进入刺激电流时相的比例明显增加。刺激频率的子集修改了CA1与局部正在进行的CA1振荡的相位的尖峰关系，每个刺激频率对下游CA1施加独特的影响，通常在目标刺激频率之外的频率范围内。这些结果表明，存在LEC-CA1通信的最佳频率，不同的LEC节律可能会对CA1的处理产生不同的结果。
The hippocampus contains rich oscillatory activity, with continuous ebbs and flows of rhythmic currents that constrain its ability to integrate inputs. During associative learning, the hippocampus must integrate inputs from a range of sources carrying information about events and the contexts in which they occur. Under these circumstances, temporal coordination of activity between sender and receiver is likely essential for successful communication. Previously, it has been shown that the coordination of rhythmic activity between the lateral entorhinal cortex (LEC) and the CA1 region of the hippocampus is tightly correlated with the onset of learning in an associative learning task. We aimed to examine whether rhythmic inputs from the LEC in specific frequency ranges were sufficient to enhance the temporal coordination of activity in downstream CA1. In urethane‐anesthetized rats, we applied extracellular low‐intensity alternating current stimulation across the length of the LEC. Using this method, we aimed to phase‐bias ongoing neuronal activity in LEC at a range of different frequencies (from 1.25 to 55 Hz). Rhythmic stimulation of LEC at both 35 and 50 Hz increased the proportion of CA1 neurons significantly entrained to the phase of the applied stimulation current. A subset of stimulation frequencies modified CA1 spiking relationships to the phase of local ongoing CA1 oscillations, with each stimulation frequency exerting a unique influence upon downstream CA1, often in frequency ranges outside the target stimulation frequency. These results suggest there are optimal frequencies for LEC–CA1 communication, and that different profiles of LEC rhythms likely have distinct outcomes upon CA1 processing.
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影响因子：
3.7
作者：
Hakami T;Jones NC;Tolmacheva EA;Gaudias J;Chaumont J;Salzberg M;O'Brien TJ;Pinault D
通讯作者：
Pinault D
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
4.6
作者：
Caixeta FV;Cornélio AM;Scheffer-Teixeira R;Ribeiro S;Tort AB
通讯作者：
Tort AB
影响因子：
3.4
作者：
Kinnavane, L.;Amin, E.;Aggleton, J. P.
通讯作者：
Aggleton, J. P.