The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm.
The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm.
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DOI：
10.3389/fimmu.2022.865395
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发表时间：
2022
影响因子：
7.3
通讯作者：
De Trez, Carl
中科院分区：
文献类型：
--
作者：
Stijlemans, Benoit;Schoovaerts, Maxime;De Baetselier, Patrick;Magez, Stefan;De Trez, Carl
非洲锥虫是由采采蝇传播的细胞外有鞭毛的单细胞原生动物寄生虫，引起人类昏睡病和牛和其他牲畜的Nagana病。这些疾病的特征通常是如果不治疗，会发展成致命的慢性炎性疾病。在非洲锥虫感染和许多其他感染性疾病期间，免疫反应正在介导有效/保护性免疫与过度感染诱导的炎症之间的跷跷板平衡，过度感染诱导的炎症可能导致附带组织损伤。已知非洲锥虫会引发强烈的I型促炎反应，这有助于控制寄生虫病的高峰，但如果不严格控制，这可能最终导致免疫病理学的发展，如贫血和肝损伤。在这种情况下，巨噬细胞移动抑制因子（MIF）和白细胞介素-10（IL-10）细胞因子可能作为一个分子的“阴阳”在非洲锥虫感染，并可能在其他感染性疾病的宿主免疫微环境的调制。MIF是一种多效性促炎细胞因子，是免疫和炎症反应的关键上游介质，与过度炎症和免疫病理学相关。例如，它在针对非洲锥虫和其他病原体的促炎反应中发挥关键作用，从而促进免疫病理学的发展。另一方面，IL-10是一种抗炎细胞因子，在非洲锥虫病和其他疾病中充当炎症的主要调节剂。IL-10对于抵消强烈的MIF诱导的促炎反应至关重要，从而导致病理控制。因此，能够阻断MIF和/或促进IL-10受体信号传导途径的新策略可以潜在地用作在非洲锥虫感染期间以及在其他感染性病症期间抵抗免疫病理学发展的疗法。总之，这篇评论的目的是总结目前的知识相反的免疫病理分子的“阴阳”开关的MIF和IL-10在感染过程中的宿主免疫微环境的调制作用，更特别是在非洲锥虫病作为一个范例。
African trypanosomes are extracellular flagellated unicellular protozoan parasites transmitted by tsetse flies and causing Sleeping Sickness disease in humans and Nagana disease in cattle and other livestock. These diseases are usually characterized by the development of a fatal chronic inflammatory disease if left untreated. During African trypanosome infection and many other infectious diseases, the immune response is mediating a see-saw balance between effective/protective immunity and excessive infection-induced inflammation that can cause collateral tissue damage. African trypanosomes are known to trigger a strong type I pro-inflammatory response, which contributes to peak parasitaemia control, but this can culminate into the development of immunopathologies, such as anaemia and liver injury, if not tightly controlled. In this context, the macrophage migration inhibitory factor (MIF) and the interleukin-10 (IL-10) cytokines may operate as a molecular “Yin-Yang” in the modulation of the host immune microenvironment during African trypanosome infection, and possibly other infectious diseases. MIF is a pleiotropic pro-inflammatory cytokine and critical upstream mediator of immune and inflammatory responses, associated with exaggerated inflammation and immunopathology. For example, it plays a crucial role in the pro-inflammatory response against African trypanosomes and other pathogens, thereby promoting the development of immunopathologies. On the other hand, IL-10 is an anti-inflammatory cytokine, acting as a master regulator of inflammation during both African trypanosomiasis and other diseases. IL-10 is crucial to counteract the strong MIF-induced pro-inflammatory response, leading to pathology control. Hence, novel strategies capable of blocking MIF and/or promoting IL-10 receptor signaling pathways, could potentially be used as therapy to counteract immunopathology development during African trypanosome infection, as well as during other infectious conditions. Together, this review aims at summarizing the current knowledge on the opposite immunopathological molecular “Yin-Yang” switch roles of MIF and IL-10 in the modulation of the host immune microenvironment during infection, and more particularly during African trypanosomiasis as a paradigm.
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影响因子：
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作者：
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白介素（IL）-10在愈合后皮肤中持续的持久性以及抗IL-10受体抗体对无菌治疗的治疗潜力的作用。
DOI：
10.1084/jem.194.10.1497
发表时间：
2001-11-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Belkaid Y;Hoffmann KF;Mendez S;Kamhawi S;Udey MC;Wynn TA;Sacks DL
通讯作者：
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