Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.

Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.
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链球菌表面糖蛋白 GspB 和 Hsa 与人唾液蛋白的结合。

DOI:
10.1128/iai.74.3.1933-1940.2006
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发表时间:
2006
期刊:
Infection and immunity.
影响因子:
--
通讯作者:
Sullam,PaulM
Sullam,PaulM
中科院分区:
--
文献类型:
--
作者:
Takamatsu,Daisuke;Bensing,BarbaraA;Prakobphol,Akraporn;Fisher,SusanJ;Sullam,PaulM

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GspB和HSA是戈登链球菌的同源表面糖蛋白,与血小板膜糖蛋白Ib、α上的唾液酸部分结合。由于该物种是口腔菌群的重要成员,我们研究了这些粘附素与人类唾液蛋白的直接结合。GspB和HSA都能结合低分子唾液粘蛋白mg2和唾液凝集素。HSA还结合了其他几种唾液蛋白,包括分泌型免疫球蛋白A。对六株口腔链球菌的筛选显示,至少有两株菌株表达GspB同源物。这些结果表明,GspB样黏附素可能在口腔细菌定植中起重要作用。
GspB and Hsa are homologous surface glycoproteins ofStreptococcus gordoniithat bind sialic acid moieties on platelet membrane glycoprotein Ibα. Since this species is an important member of the oral flora, we examined the direct binding of these adhesins to human salivary proteins. Both GspB and Hsa bound low-molecular-weight salivary mucin MG2 and salivary agglutinin. Hsa also bound several other salivary proteins, including secretory immunoglobulin A. Screening of six oral streptococcal isolates revealed that at least two of the strains expressed GspB homologues. These results indicate that GspB-like adhesins may be important for oral bacterial colonization.
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发表时间: 1998-03
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影响因子: 2.9
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