SiBaoChongCao exhibited anti-fatigue activities and ameliorated cancer cachexia in mice.
SiBaoChongCao exhibited anti-fatigue activities and ameliorated cancer cachexia in mice.
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四宝虫草在小鼠体内表现出抗疲劳活性并改善癌症恶病质
作者：
四宝虫草(SBCC)是冬虫夏草属植物土生顶藻发酵而成的一种功能食品。−-1 1和2g·kg-1灌胃给药20d，小鼠力竭游泳和跑时间延长，肌肉力量增加。小鼠肌肉耐力的提高可能与促进肌肉细胞的生长和分化，改善肌肉对运动的反应有关，表现为肌肉横截面积的增加和MHC、MyoD、MyoG和PGC-1α水平的升高。SBCC1.5g kg−-1可改善癌性恶病质，如改善体温下降、抑制脂肪组织萎缩等。SBCC的抗恶病质作用可能与其通过抑制AMPK和p38MAPK的激活，下调UCP1水平，抑制炎症细胞因子IL-6的分泌，抑制脂质过度分解和脂质过度利用有关。SBCC通过提高肌肉耐力表现出抗疲劳的活性，并通过减轻脂肪损失和体温来改善癌症恶病质。
SiBaoChongCao (SBCC) is a functional food product containing fermentation of Acremonium terricola belonging to the Cordyceps genus. SBCC at 1 and 2 g kg−1 for 20 days exhibited anti-fatigue activities such as increasing exhaustive swimming and running time of mice and increasing the strength of muscle. The increased muscle endurance in SBCC-treated mice might be related to enhancement of muscle cell growth and differentiation and improvement of muscle response to exercise training, as shown by an increase in muscle cross-sectional area and elevation of MHC, MyoD, MyoG and PGC-1α levels. And, SBCC at 1.5 g kg−1 could ameliorate cancer-related cachexia such as ameliorating decrease in body temperature and inhibiting fat tissue atrophy. The anti-cachexia effects of SBCC might be related to inhibition of inflammatory cytokine IL-6 secretion and suppression of over-lipolysis and lipid over-utilization through inhibiting the activation of AMPK and p38 MAPK and down-regulating the level of UCP1. SBCC exhibits anti-fatigue activity by improving muscle endurance and ameliorates cancer cachexia by alleviating loss of fat and body temperature.
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影响因子：
2.7
作者：
Liu J;DU C;Wang Y;Yu Z
通讯作者：
Yu Z
影响因子：
5.3
作者：
Kim, Sun-Joong;Tang, Tianyi;Sul, Hei Sook
通讯作者：
Sul, Hei Sook
影响因子：
5.6
作者：
Chen, Xiaoling;Guo, Yafei;Huang, Zhiqing
通讯作者：
Huang, Zhiqing
影响因子：
2.8
作者：
Cong Ming-Hua;Zou Bao-Hua;Yu Lei
通讯作者：
Yu Lei
DOI：
10.1016/j.ijbiomac.2015.06.055
发表时间：
2015-09-01
影响因子：
8.2
作者：
Chi, Aiping;Li, Hong;Tang, Liang
通讯作者：
Tang, Liang