Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus.
Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus.
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DOI：
10.3892/etm.2014.2139
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发表时间：
2015-02
影响因子：
2.7
通讯作者：
Yu Z
中科院分区：
文献类型：
--
作者：
Liu J;DU C;Wang Y;Yu Z
猴头菌(Hericium erinaceus，HEP)是一种著名的药用真菌，产于中国等东方国家。辣根多糖具有多种生理活性，近年来引起了人们的极大关注。本研究的目的是在小鼠模型上评价HEP的抗疲劳活性。习服一周后，将小鼠随机分为四组：对照组、低剂量HEP组、中剂量HEP组和高剂量HEP组。治疗组给予HEP(50、100、200 mg/kg，ig)，对照组给予生理盐水。治疗28d后，进行强迫游泳实验，直至力竭，记录力竭游泳时间以及与疲劳有关的某些生化指标，包括血乳酸(BLA)、血清尿素氮(SUN)、组织糖原、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)和丙二醛(MDA)。提示HEP通过降低BLA、SUN和MDA含量，提高组织糖原含量和抗氧化酶活性，具有显著的抗疲劳作用。本研究为HEP在运动营养领域的应用提供了理论支持。
Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. After one week of acclimation, mice were randomly divided into four groups: a control group, a low-dose HEP-treated group, a moderate-dose HEP-treated group, and a high-dose HEP-treated group. The treated groups received HEP (50, 100 and 200 mg/kg, ig), while the control group received saline solution. Following treatment for 28 days, the mice performed a forced swimming test until they were exhausted, then the exhaustive swimming time was recorded along with certain biochemical parameters related to fatigue, including blood lactic acid (BLA), serum urea nitrogen (SUN), tissue glycogen, superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). These results suggested that HEP has significant anti-fatigue activity by decreasing BLA, SUN and MDA content, as well as increasing tissue glycogen content and antioxidant enzyme activity. Based on these results, this study provided theoretical support for the application of HEP in the field of sports nutrition.
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影响因子：
--
作者：
Khan, Md Asaduzzaman;Tania, Mousumi;Rahman, Mohammad Mijanur
通讯作者：
Rahman, Mohammad Mijanur
DOI：
10.1155/2012/364741
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Huang CC;Hsu MC;Huang WC;Yang HR;Hou CC
通讯作者：
Hou CC
影响因子：
3
作者：
Wang, Li;Zhang, Hua-Li;Yao, Zhi
通讯作者：
Yao, Zhi
DOI：
10.3923/rjmp.2012.37.46
发表时间：
2012-01-01
期刊：
Research Journal of Medicinal Plant
影响因子：
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作者：
Prasad, M. P. V.;Farhath Khanum, Farhath Khanum;Khanum, F.
通讯作者：
Khanum, F.
影响因子：
7.2
作者：
Anand, T.;Kumar, G. Phani;Bawa, A. S.
通讯作者：
Bawa, A. S.