Molecular methods to describe the spectrum and dynamics of the vaginal microbiota.
Molecular methods to describe the spectrum and dynamics of the vaginal microbiota.
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DOI：
10.1016/j.anaerobe.2011.01.001
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发表时间：
2011-08
期刊：
影响因子：
2.3
通讯作者：
Fredricks, David N.
中科院分区：
文献类型：
--
作者：
Fredricks, David N.
关键词：
人类阴道中的微生物集合与其他人体表面和粘膜部位不同，微生物多样性减少，这可能是由酸性环境驱动的。在没有细菌性阴道病（BV）的女性中，阴道的微生物生态系统以乳酸杆菌为主，其特征在于BV女性中的物种丰富度，多样性和均匀性增加。使用分子，培养独立的方法来描述人类阴道的细菌生物群，揭示了许多新的假定的厌氧菌在女性BV，并证明了几乎无处不在的性质，乳杆菌iners发现在大多数妇女，无论BV状态。各种分子工具正在被用来研究阴道微生物群，每种方法都有不同的优点和缺点。纵向研究表明，阴道微生物群可以是高度动态的，细菌组成和浓度响应于许多内源性和外源性因素而发生急剧变化。
The human vagina hosts a collection of microbes that is distinct from other human surfaces and mucosal sites, with reduced microbial diversity that is likely driven by the acidic environment. The microbial ecosystem of the vagina is dominated by lactobacilli in women without bacterial vaginosis (BV), and is characterize by increased species richness, diversity, and evenness in women with BV. The use of molecular, cultivation-independent methods to describe the bacterial biota of the human vagina has revealed many novel putative anaerobes in women with BV, and has demonstrated the almost ubiquitous nature of Lactobacillus iners which is found in most women regardless of BV status. A variety of molecular tools are being employed to study the vaginal microbiota, and each approach has distinct advantages and disadvantages that are reviewed. Longitudinal studies have demonstrated that the vaginal microbiota can be highly dynamic, with dramatic shifts in bacterial composition and concentrations in response to numerous endogenous and exogenous factors.
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影响因子：
17.1
作者：
Turnbaugh PJ;Ridaura VK;Faith JJ;Rey FE;Knight R;Gordon JI
通讯作者：
Gordon JI
影响因子：
3.1
作者：
Fredricks, David N;Marrazzo, Jeanne M
通讯作者：
Marrazzo, Jeanne M
影响因子：
3.7
作者：
Srinivasan S;Liu C;Mitchell CM;Fiedler TL;Thomas KK;Agnew KJ;Marrazzo JM;Fredricks DN
通讯作者：
Fredricks DN
影响因子：
9.4
作者：
Fredricks, David N.;Fiedler, Tina L.;Marrazzo, Jeanne M.
通讯作者：
Marrazzo, Jeanne M.
影响因子：
9.4
作者：
Fredricks, David N.;Fiedler, Tina L.;Marrazzo, Jeanne M.
通讯作者：
Marrazzo, Jeanne M.