Olfactory Dysfunction and Its Association With Neuropathologic Proteins in Cerebrospinal Fluid From Patients With Parkinson Disease.
Olfactory Dysfunction and Its Association With Neuropathologic Proteins in Cerebrospinal Fluid From Patients With Parkinson Disease.
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DOI：
10.3389/fnagi.2020.594324
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发表时间：
2020
影响因子：
4.8
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Guo P;Wang RD;Lian TH;Ding DY;Zhang YN;Zhang WJ;Li DN;Li LX;Li JH;Guan HY;Yu SY;Liu L;Hu Y;Zuo LJ;Yu QJ;Wang XM;Zhang W
背景与目的：嗅觉功能障碍（Olfactory dysfunction，OD）是帕金森病（Parkinson disease，PD）常见的非运动症状。然而，PD患者脑脊液（CSF）中OD和神经病理蛋白之间的关系尚不清楚。方法：166例PD患者纳入研究。采用嗅棒试验对患者的嗅觉阈值、辨别力和识别力进行评分，并根据评分结果将患者分为PD伴OD（PD-OD）和PD不伴OD（PD-NOD）两组。从76例PD患者中获得CSF样本。采用酶联免疫吸附试验测定脑脊液中神经病理蛋白的水平，包括α-Synuclein、Aβ1-42、总tau蛋白（T-tau）和多种形式的磷酸化tau蛋白（P-tau）。结果：166例PD患者中，103例（62.0%）发生OD。PD-OD组的嗅觉功能总分、嗅觉阈值、辨别力和识别力均显著低于PD-NOD组（P < 0.001）。PD-OD组脑脊液中α-Synuclein水平显著高于PD-NOD组（P < 0.05），且与总体嗅觉功能评分、嗅觉辨别和识别评分呈显著负相关（P < 0.05）。PD-OD组脑脊液Aβ1-42水平高于PD-NOD组，且与嗅觉识别评分呈显著负相关（P <0. 05）。PD-OD组脑脊液中T-tau水平显著低于PD-NOD组（P < 0.05），且与嗅觉辨别评分呈显著正相关（P < 0.05）。PD-OD组和PD-NOD组CSF中P-tau水平无显著性差异，OD评分与CSF中P-tau水平无相关性。结论：PD-OD包括嗅觉阈值、辨别力和识别力的损害，并与CSF中α-Synuclein的显著升高和T-tau水平的降低有关。
Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear. Methods: 166 PD patients were included in the study. Overall olfactory function was assessed by summing up the scores of olfactory threshold, discrimination, and identification by a Sniffin' Sticks test, based on which, patients were divided into PD with OD (PD-OD) and PD with no OD (PD-NOD) groups. CSF samples were obtained from 76 PD patients. The levels of neuropathologic proteins, including α-Synuclein, Aβ1-42, total tau (T-tau), and multiple forms of phosphorylated tau (P-tau) in CSF were measured by an enzyme-linked immunosorbent assay. Results: out of the 166 PD patients, 103 cases (62.0%) had OD. The scores of overall olfactory functions, and olfactory threshold, discrimination, and identification in the PD-OD group were all significantly lower than that in the PD-NOD group (P < 0.001). α-Synuclein level in CSF was significantly higher in the PD-OD group than the PD-NOD group (P < 0.05), and was significantly and negatively correlated with the scores of overall olfactory function, and olfactory discrimination and identification (P < 0.05). Aβ1-42 level in CSF was higher in the PD-OD group than the PD-NOD group, and was significantly and negatively correlated with the olfactory identification score (P < 0.05). T-tau level in CSF was significantly lower in the PD-OD group than the PD-NOD group (P < 0.05), and was significantly and positively correlated with the olfactory discrimination score (P < 0.05). There was no significant difference in P-tau level in CSF between the PD-OD and PD-NOD groups and no correlation between OD score and P-tau level in CSF. Conclusions: PD-OD includes the impairments of olfactory threshold, discrimination, and identification, and is associated with the significant elevation of α-Synuclein and the decrease of the T-tau level in CSF.
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影响因子：
8.6
作者：
Mahlknecht, Philipp;Pechlaner, Raimund;Boesveldt, Sanne;Volc, Dieter;Pinter, Bernardette;Reiter, Eva;Mueller, Christoph;Krismer, Florian;Berendse, Henk W.;van Hilten, Jacobus J.;Wuschitz, Albert;Schimetta, Wolfgang;Hoegl, Birgit;Djamshidian, Atbin;Nocker, Michael;Goebel, Georg;Gasperi, Arno;Kiechl, Stefan;Willeit, Johann;Poewe, Werner;Seppi, Klaus
通讯作者：
Seppi, Klaus
影响因子：
11.2
作者：
Goris, An;Williams-Gray, Caroline H.;Sawcer, Stephen J.
通讯作者：
Sawcer, Stephen J.
影响因子：
3.5
作者：
Lindstrom, Veronica;Gustafsson, Gabriel;Erlandsson, Anna
通讯作者：
Erlandsson, Anna
影响因子：
11
作者：
Ponsen, Mirthe M.;Stoffers, Diederick;Berendse, Henk W.
通讯作者：
Berendse, Henk W.
影响因子：
8.6
作者：
Pont-Sunyer, Claustre;Hotter, Anna;Tolosa, Eduardo
通讯作者：
Tolosa, Eduardo