Sex-specific effects of maternal weight loss on offspring cardiometabolic outcomes in the obese preeclamptic-like mouse model, BPH/5.
Sex-specific effects of maternal weight loss on offspring cardiometabolic outcomes in the obese preeclamptic-like mouse model, BPH/5.
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DOI：
10.14814/phy2.15444
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发表时间：
2022-09
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
子痫前期（Preeclampsia，PE）是一种高血压疾病，在全球范围内约有2-8%的孕妇患有此病.其特征是在妊娠后半期新发高血压，是孕产妇和胎儿发病/死亡的主要原因。母亲肥胖会增加PE的风险，并且是儿童肥胖的关键预测因素，并可能以性别依赖的方式产生后代心脏代谢并发症。母亲的致肥环境，叠加PE，对后代发育成成年期的影响是未知的。肥胖BPH/5小鼠自发表现出妊娠晚期高血压、胎儿死亡和生长受限以及妊娠期体重过度增加。BPH/5女性在怀孕开始时通过配对喂养减轻母体体重时改善了妊娠结局。我们假设，雌性和雄性BPH/5后代之间的表型差异可能会受到怀孕期间配对喂养BPH/5母鼠的影响。BPH/5配对喂养的母鼠改善了窝仔数，并增加了胎仔体重。自由采食母鼠产下的BPH/5后代具有相似的性别比、体重和粪便微生物组，以及母鼠配对喂养后代中降低的血压升高。配对喂养的母鼠所生的BPH/5雄性和雌性后代的肥胖率降低，肠道微生物组改变，而只有配对喂养的母鼠所生的雌性后代的循环瘦素和白色脂肪组织炎性细胞因子降低。这些性别二态性结果表明，妊娠早期母体致肥环境的减少可能在女性BPH/5性别依赖性心脏代谢结局中发挥比男性更大的作用。重新编程女性可以减轻心脏代谢疾病的跨代进展。
AbstractPreeclampsia (PE) is a hypertensive disorder that impacts 2–8% of pregnant women worldwide. It is characterized by new onset hypertension during the second half of gestation and is a leading cause of maternal and fetal morbidity/mortality. Maternal obesity increases the risk of PE and is a key predictor of childhood obesity and potentially offspring cardiometabolic complications in a sex‐dependent manner. The influence of the maternal obesogenic environment, with superimposed PE, on offspring development into adulthood is unknown. Obese BPH/5 mice spontaneously exhibit late‐gestational hypertension, fetal demise and growth restriction, and excessive gestational weight gain. BPH/5 females have improved pregnancy outcomes when maternal weight loss via pair‐feeding is imposed beginning at conception. We hypothesized that phenotypic differences between female and male BPH/5 offspring can be influenced by pair feeding BPH/5 dams during pregnancy. BPH/5 pair‐fed dams have improved litter sizes and increased fetal body weights. BPH/5 offspring born to ad libitum dams have similar sex ratios, body weights, and fecal microbiome as well as increased blood pressure that is reduced in the dam pair‐fed offspring. Both BPH/5 male and female offspring born to pair‐fed dams have a reduction in adiposity and an altered gut microbiome, while only female offspring born to pair‐fed dams have decreased circulating leptin and white adipose tissue inflammatory cytokines. These sexually dimorphic results suggest that reduction in the maternal obesogenic environment in early pregnancy may play a greater role in female BPH/5 sex‐dependent cardiometabolic outcomes than males. Reprograming females may mitigate the transgenerational progression of cardiometabolic disease.
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DOI：
10.2460/javma.232.9.1345
发表时间：
2008-05-01
影响因子：
1.9
作者：
Arnold, Carolyn E.;Payne, Maria;Bain, Fairfield T.
通讯作者：
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DOI：
10.1161/hypertensionaha.116.06602
发表时间：
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期刊：
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发表时间：
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影响因子：
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通讯作者：
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影响因子：
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