Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.
Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.
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抑制 p300 依赖性 mdm2 负反馈环路会诱导 p53 凋亡功能。
DOI：
10.1101/gad.12.13.1975
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发表时间：
1998
影响因子：
10.5
通讯作者：
White,E
中科院分区：
文献类型：
--
作者：
Thomas,A;White,E
The p53 tumor suppressor gene product interacts with the p300 transcriptional coactivator that regulates the transactivation of p53-inducible genes. The adenovirus E1A protein has been shown to bind to p300 and inhibit its function. E1A inhibits p53 transactivation and also promotes p53 accumulation by a p300-dependent mechanism. Murine double minute 2 (Mdm2) is a transcriptional target of p53 that binds to p53 and inhibits its transcriptional activity. E1A inhibitedmdm2transactivation without affecting the expression ofp21WAF1orBax,which resulted in high levels of p53 accumulation and apoptosis. Ectopic expression of p300 restored Mdm2 levels and inhibited p53-dependent apoptosis, as did ectopic expression of Mdm2. Thus, p300 is required formdm2induction by p53 and the subsequent inhibition of p53 stabilization. Inhibition of p300 by E1A results in stabilization of p53 and causes apoptosis. Moreover, E1B 19K or Bcl-2 expression in E1A-transformed cells abrogated p53-dependent apoptosis by restoringmdm2transactivation by p53. Hence, p300 regulation ofmdm2expression controls apoptotic activity of p53, and 19K or Bcl-2 bypass E1A inhibition of p300 transactivation of Mdm2.
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DOI：
10.1073/pnas.91.6.1998
发表时间：
1994-03-15
影响因子：
11.1
作者：
PIETENPOL, JA;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
DOI：
10.1073/pnas.91.19.8940
发表时间：
1994-09
影响因子：
11.1
作者：
Yuqiao Shen;Thomas Shenk
通讯作者：
Yuqiao Shen;Thomas Shenk
影响因子：
4
作者：
Rao, L;White, E
通讯作者：
White, E
由人类巨细胞病毒的两个协同 DNA 片段介导的肿瘤进展。
影响因子：
5.4
作者：
Jariwalla,RJ;Razzaque,A;Lawson,S;Rosenthal,LJ
通讯作者：
Rosenthal,LJ
影响因子：
10.5
作者：
Han, JH;Sabbatini, P;White, E
通讯作者：
White, E