Tumor progression mediated by two cooperating DNA segments of human cytomegalovirus.
Tumor progression mediated by two cooperating DNA segments of human cytomegalovirus.
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由人类巨细胞病毒的两个协同 DNA 片段介导的肿瘤进展。
DOI：
10.1128/jvi.63.1.425-428.1989
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发表时间：
1989
影响因子：
5.4
通讯作者：
Rosenthal,LJ
中科院分区：
文献类型：
--
作者：
Jariwalla,RJ;Razzaque,A;Lawson,S;Rosenthal,LJ
The terminal fragments (EJ and EM) of the XbaI-E transforming segment of human cytomegalovirus can independently induce the tumorigenic conversion of immortalized cells. To study their interaction, Rat-2 cells were transfected singly or with a combination of cloned EJ and EM DNAs. Large transformed foci were induced at a 10-fold higher frequency by EJ plus EM than by either DNA fragment alone. Focus-derived lines transformed by EJ plus EM produced tumors in syngeneic rats at a much faster rate (5 to 7 days) than did cell lines transformed by EJ or EM alone (25 to 35 days). Southern hybridizations showed that EM-homologous DNA was retained, exhibiting a complex pattern of multiple and amplified bands in EJ-plus-EM lines compared to a simple pattern in EM-induced lines. EJ DNA was not detected in the single or double transformants. The levels of p29, a 29-kilodalton transformation-sensitive marker in Rat-2 cells, were decreased 10- to 100-fold in cell lines transformed by EJ or EM fragment alone. Synthesis of p29 was shut off in EJ- plus-EM transformants. These data demonstrate that two unlinked transforming regions of human cytomegalovirus can cooperate to produce an aggressive tumorigenic phenotype.
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影响因子：
3.4
作者：
JERNIGAN, HM;FUKUI, HN;KINOSHITA, JH
通讯作者：
KINOSHITA, JH
磷脂前体的高效液相色谱分离及其自动磷分析直接测量
影响因子：
4.1
作者：
J. Kaitaranta;P. Geiger;S. Bessman
通讯作者：
S. Bessman
晶状体中磷酰胆碱和磷酰乙醇胺的浓度。
影响因子：
3.4
作者：
P. Zelenka;H. M. Jernigan
通讯作者：
H. M. Jernigan
通过 P-31 NMR 光谱分析完整的大鼠晶状体代谢物。
影响因子：
2
作者：
S. J. Kopp;J. Greiner;T. Glonek
通讯作者：
T. Glonek
自动磷酸酯色谱法中磷脂代谢成分的鉴定。
DOI：
10.1016/0006-291x(79)92077-1
发表时间：
1979
影响因子：
3.1
作者：
P. Geiger;C. M. Roberts
通讯作者：
C. M. Roberts