Altered effective connectivity in the emotional network induced by immersive virtual reality rehabilitation for post-stroke depression.
Altered effective connectivity in the emotional network induced by immersive virtual reality rehabilitation for post-stroke depression.
复制标题
改变了由沉浸式虚拟现实康复治疗中风后抑郁症引起的情感网络中的有效连接。
DOI：
10.3389/fnhum.2022.974393
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发表时间：
2022
影响因子：
2.9
通讯作者：
Xu, Jian-Guang
中科院分区：
文献类型：
--
作者：
Wu, Jia-Jia;Zheng, Mou-Xiong;Hua, Xu-Yun;Wei, Dong;Xue, Xin;Li, Yu-Lin;Xing, Xiang-Xin;Ma, Jie;Shan, Chun-Lei;Xu, Jian-Guang
关键词：
中风后抑郁（PSD）是中风的一种严重并发症，严重限制康复。对中风幸存者使用沉浸式虚拟现实是有希望的。在此，我们研究了新型沉浸式虚拟现实训练系统对 PSD 的影响，并使用多元格兰杰因果分析 (GCA) 探索了情感网络中诱导有效连接性的改变。 44 名 PSD 患者被平均分配到沉浸式虚拟现实组和对照组。除了常规的康复治疗外，沉浸式虚拟现实组的参与者还参加了沉浸式虚拟现实康复项目，而对照组的患者则接受了二维虚拟现实康复训练。在为期 4 周的干预前后收集汉密尔顿抑郁量表、改良巴塞尔指数 (MBI) 和静息态功能磁共振成像 (rsfMRI) 数据。使用多变量 GCA 分析 rsfMRI 数据。我们发现，沉浸式虚拟现实训练对于改善 PSD 患者的抑郁症更有效，但与对照组相比，MBI 评分没有统计学上的显着改善。 GCA表明，沉浸式虚拟现实训练后以下因果连接得到加强：从杏仁核、岛叶、颞中回和尾状核到背外侧前额叶皮层；从岛叶到内侧前额皮质；以及从丘脑到颞上后沟。对照组治疗后这些因果联系被削弱。我们的结果表明，沉浸式虚拟现实康复的神经治疗方法可作为 PSD 的有效非药物干预措施；情感网络中因果连接的改变可能构成 PSD 沉浸式虚拟现实康复的神经机制。
Post-stroke depression (PSD) is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis (GCA). Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index (MBI), and resting-state functional magnetic resonance imaging (rsfMRI) data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD.
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影响因子：
3.5
作者：
Fernández-Caballero A;Navarro E;Fernández-Sotos P;González P;Ricarte JJ;Latorre JM;Rodriguez-Jimenez R
通讯作者：
Rodriguez-Jimenez R
影响因子：
4.3
作者：
Pan, Chensheng;Li, Guo;Sun, Wenzhe;Miao, Jinfeng;Qiu, Xiuli;Lan, Yan;Wang, Yanyan;Wang, He;Zhu, Zhou;Zhu, Suiqiang
通讯作者：
Zhu, Suiqiang
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
中风后抑郁情绪网络的调查：功能磁共振成像数据的多元格兰杰因果分析研究
影响因子：
6.6
作者：
Shi Yu;Liu Wei;Wu Wen
通讯作者：
Wu Wen
影响因子：
3
作者：
Herbert, Beate M.;Pollatos, Olga
通讯作者：
Pollatos, Olga