Neurovascular coupling: motive unknown.
Neurovascular coupling: motive unknown.
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DOI：
10.1016/j.tins.2022.08.004
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发表时间：
2022-11
影响因子：
15.9
通讯作者：
Drew, Patrick J.
中科院分区：
文献类型：
--
作者：
Drew, Patrick J.
世纪以来，人们已经知道大脑中神经活动的增加会驱动局部血流的变化，称为神经血管耦合。对大脑中这些血流量增加（称为功能性充血）的通俗解释是，它们用于供应代谢活性神经元的需求。然而，有大量的证据与这一想法不一致。在大多数情况下，基线血流量足以提供甚至升高的神经活动。在许多脑区、行为状态和条件下，神经血管耦合是不规则的、缺失的或倒置的。呼吸的增加可以独立于流量变化而产生脑氧合的增加。模拟已经显示，具有低血流量的区域是不可避免的，并且在给定脑血管结构的情况下不能通过功能性充血去除。神经血管偶联有什么生理作用？在这里，我们讨论潜在的替代功能的神经血管耦合。它可以为神经调节剂的合成提供氧气，调节脑温度，向神经元发送信号，稳定和优化脑血管结构，处理血液的非牛顿性质，或通过动脉扩张驱动脑脊髓液的产生和循环。了解神经血管耦合的“原因”是了解脑血管功能障碍引起的病理学的重要目标。
It has been known for more than century that increases in neural activity in the brain drive changes in local blood flow, known as neurovascular coupling. The colloquial explanation for these increases in blood flow (referred to as functional hyperemia) in the brain is that they serve to supply the needs of metabolically active neurons. However, there is an large body of evidence that is inconsistent with this idea. In most cases, baseline blood flow is adequate to supply even elevated neural activity. Neurovascular coupling is irregular, absent, or inverted in many brain regions, behavioral states, and conditions. Increases in respiration can generate increases in brain oxygenation independently of flow changes. Simulations have shown that areas with low blood flow are inescapable and cannot be removed by functional hyperemia given the architecture of the cerebral vasculature. What physiological purpose might neurovascular coupling serve? Here, we discuss potential alternative functions of neurovascular coupling. It may serve supply oxygen for neuromodulator synthesis, to regulate cerebral temperature, signal to neurons, stabilize and optimize the cerebral vascular structure, deal with the non-Newtonian nature of blood, or drive the production and circulation of cerebrospinal fluid around and through the brain via arterial dilations. Understanding the ‘why’ of neurovascular coupling is an important goal that give insight into the pathologies caused by cerebrovascular disfunction.
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影响因子：
9.8
作者：
Chen Q;Jiang L;Li C;Hu D;Bu JW;Cai D;Du JL
通讯作者：
Du JL
DOI：
10.3389/fnene.2010.00008
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Buxton RB
通讯作者：
Buxton RB
DOI：
10.1073/pnas.2133652100
发表时间：
2003-10-28
影响因子：
11.1
作者：
Chaigneau, E;Oheim, M;Charpak, S
通讯作者：
Charpak, S
影响因子：
4.6
作者：
Adams MD;Winder AT;Blinder P;Drew PJ
通讯作者：
Drew PJ
影响因子：
6.3
作者：
Bekar, Lane K.;Wei, Helen S.;Nedergaard, Maiken
通讯作者：
Nedergaard, Maiken