Quantitative time-of-flight MR angiography for simultaneous luminal and hemodynamic evaluation of the intracranial arteries.
Quantitative time-of-flight MR angiography for simultaneous luminal and hemodynamic evaluation of the intracranial arteries.
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DOI：
10.1002/mrm.28969
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发表时间：
2022-01
影响因子：
3.3
通讯作者：
Edelman RR
中科院分区：
文献类型：
--
作者：
Koktzoglou I;Huang R;Edelman RR
报告一种定量飞行时间（qTOF）MR血管造影（MRA）技术，用于同时评价颅内动脉的管腔和血流动力学。使用基于3-回波快速低角度激发读数的薄重叠平板3D星状堆叠实施，在流动体模中测试qTOF，并在3 T下对10名人类受试者的颅内动脉进行成像。将qTOF颅内动脉显示与分辨率匹配和扫描时间匹配的标准笛卡尔3D飞行时间（TOF）MRA进行比较，而将使用基于计算机视觉的回波间图像分析程序进行的qTOF平均血流速度定量与3D相位对比（PC）MRA进行比较。测量动脉与背景的对比噪声比（CNR），并使用组内相关系数（ICC）评价流速的一致性。对于扫描时间相似的分辨率匹配方案，qTOF描绘的颅内动脉与标准笛卡尔TOF具有良好的形态学相关性，与PC相比，两种技术均提供了上级CNR和动脉描绘（20.6±3.0和37.8±8.7 vs 11.5±2.2，P<0.001，两种比较）。就PC而言，qTOF与测量流动体模中的平均流速具有良好的一致性（ICC=0.981，P<0.001），与测量颅内动脉中的平均流速具有良好的一致性（ICC=0.700，P<0.001）。与qTOF一起使用的Stack-of-Star数据采样消除了与标准笛卡尔TOF一起看到的倾斜面内流配准不良伪影。qTOF是一种新的3D MRA技术，用于颅内动脉的同时管腔和血流动力学评价，其CNR效率显著高于PC，并消除了标准3D TOF发生的倾斜面内血流的配准不良伪影。
To report a quantitative time-of-flight (qTOF) MR angiographic (MRA) technique for simultaneous luminal and hemodynamic evaluation of the intracranial arteries. Implemented using a thin overlapping slab 3D stack-of-stars based 3-echo fast low angle shot readout, qTOF was tested in a flow phantom and for imaging the intracranial arteries of 10 human subjects at 3T. Display of the intracranial arteries with qTOF was compared to resolution-matched and scan time-matched standard Cartesian 3D time-of-flight (TOF) MRA, whereas quantification of mean blood flow velocity with qTOF, done using a computer vision-based inter-echo image analysis procedure, was compared to 3D phase contrast (PC) MRA. Arterial-to-background contrast-to-noise ratio (CNR) was measured and intraclass correlation coefficient (ICC) was used to evaluate agreement of flow velocities. For resolution-matched protocols of similar scan time, qTOF portrayed the intracranial arteries with good morphological correlation with standard Cartesian TOF, and both techniques provided superior CNR and arterial delineation compared to PC (20.6±3.0 and 37.8±8.7 versus 11.5±2.2, P<0.001, both comparisons). With respect to PC, qTOF showed excellent agreement for measuring mean flow velocity in the flow phantom (ICC=0.981, P<0.001) and good agreement in the intracranial arteries (ICC=0.700, P<0.001). Stack-of-stars data sampling used with qTOF eliminated oblique in-plane flow misregistration artifacts that were seen with standard Cartesian TOF. qTOF is a new 3D MRA technique for simultaneous luminal and hemodynamic evaluation of the intracranial arteries that provides significantly greater CNR efficiency than PC and eliminates misregistration artifacts from oblique in-plane blood flow that occur with standard 3D TOF.
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DOI：
10.1186/s12968-020-00685-1
发表时间：
2020-11-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Aouad P;Koktzoglou I;Milani B;Serhal A;Nazari J;Edelman RR
通讯作者：
Edelman RR
影响因子：
1.9
作者：
Doepp, Florian;Valdueza, Jose M.;Schreiber, Stephan J.
通讯作者：
Schreiber, Stephan J.
影响因子：
3.3
作者：
Botelho, Marcos P. Ferreira;Koktzoglou, Ioannis;Collins, Jeremy D.;Giri, Shivraman;Carr, James C.;Gupta, NavYash;Edelman, Robert R.
通讯作者：
Edelman, Robert R.
影响因子：
3.3
作者：
Edelman, Robert R.;Sheehan, John J.;Dunkle, Eugene;Schindler, Nancy;Carr, James;Koktzoglou, Ioannis
通讯作者：
Koktzoglou, Ioannis
影响因子：
3.3
作者：
Bouillot, Pierre;Delattre, Benedicte M. A.;Vargas, Maria I.
通讯作者：
Vargas, Maria I.