Differential linguistic features of verbal fluency in behavioral variant frontotemporal dementia and primary progressive aphasia.
Differential linguistic features of verbal fluency in behavioral variant frontotemporal dementia and primary progressive aphasia.
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DOI：
10.1080/23279095.2022.2060748
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发表时间：
2024-07
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--
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中科院分区：
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额颞叶痴呆（FTD）是一种早发性神经退行性疾病，具有异质性临床表现。言语流畅性通常被用作语言能力、语义记忆和执行功能的敏感指标，但目前忽视了FTD中言语流畅性的质的变化。这项回顾性研究检查了137例行为变异型（bv）FTD（n = 50）或原发性进行性失语症（PPA）患者[25例非流利变异型（nfvPPA）、27例语义变异型（svPPA）和34例逻辑缺失变异型（lvPPA）]和25例对照参与者的言语流畅性的定性语言特征。组间差异聚类，开关，词频（LF），收购年龄（AoA），邻里密度（ND），和单词长度（WL）进行了检查的类别和字母流畅性的方差分析调整年龄，性别，和单词的总数。与其他认知功能的关联进行了探讨与线性回归分析。结果表明，svPPA患者的言语流畅性表现与对照组和其他患者组相比，具有更少和更小的簇，更多的开关，更高的LF和更低的AoA（均p<0.05）。lvPPA患者特异性地产生了具有更高ND的词（p<0.05）。bvFTD组患者产生的单词比PPA组长（p<0.05）。群集，开关，LF，AoA，ND，但不是WL的差异预测的语言，记忆和执行功能的措施（范围标准化回归系数0.25-0.41）。除了单词总数之外，FTD亚型之间的定性语言特征也不同。这些功能提供了额外的信息，词汇处理和语义记忆，可能有助于FTD的鉴别诊断。
Frontotemporal dementia (FTD) is an early-onset neurodegenerative disorder with a heterogeneous clinical presentation. Verbal fluency is regularly used as a sensitive measure of language ability, semantic memory, and executive functioning, but qualitative changes in verbal fluency in FTD are currently overlooked. This retrospective study examined qualitative, linguistic features of verbal fluency in 137 patients with behavioral variant (bv)FTD (n = 50), or primary progressive aphasia (PPA) [25 non-fluent variant (nfvPPA), 27 semantic variant (svPPA), and 34 logopenic variant (lvPPA)] and 25 control participants. Between-group differences in clustering, switching, lexical frequency (LF), age of acquisition (AoA), neighborhood density (ND), and word length (WL) were examined in the category and letter fluency with analysis of variance adjusted for age, sex, and the total number of words. Associations with other cognitive functions were explored with linear regression analysis. The results showed that the verbal fluency performance of patients with svPPA could be distinguished from controls and other patient groups by fewer and smaller clusters, more switches, higher LF, and lower AoA (all p<0.05). Patients with lvPPA specifically produced words with higher ND than the other patient groups (p<0.05). Patients with bvFTD produced longer words than the PPA groups (p<0.05). Clustering, switching, LF, AoA, and ND—but not WL—were differentially predicted by measures of language, memory, and executive functioning (range standardized regression coefficient 0.25–0.41). In addition to the total number of words, qualitative linguistic features differ between subtypes of FTD. These features provide additional information on lexical processing and semantic memory that may aid the differential diagnosis of FTD.
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