Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France.
Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France.
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DOI：
10.3201/eid2701.203611
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发表时间：
2021-01
影响因子：
11.8
通讯作者：
Fafi-Kremer S
中科院分区：
文献类型：
--
作者：
Gallais F;Velay A;Nazon C;Wendling MJ;Partisani M;Sibilia J;Candon S;Fafi-Kremer S
我们在法国斯特拉斯堡调查了11对SARS-CoV-2血清不一致的夫妇（其中1对伴侣有轻度冠状病毒病（COVID-19）的证据）和10对未暴露的健康对照者中针对SARS-CoV-2和人类冠状病毒（HCoV） 229E和OC43的特异性抗体和t细胞反应。新冠肺炎确诊患者及其伴侣为密切接触者。所有指标患者均表现出sars - cov -2特异性抗体阳性和t细胞反应，并在症状出现后持续102天。所有接触者的SARS-CoV-2血清检测均呈阴性；然而，有6人在伴侣出现COVID-19症状后的中位7天内报告了症状，其中4人对3或4种SARS-CoV-2抗原表现出阳性的SARS-CoV-2特异性t细胞反应，这种反应在症状出现后持续了93天。11对夫妇和对照组对HCoV-229E或HCoV-OC43表现出阳性t细胞反应。这些数据表明，暴露于SARS-CoV-2可以诱导病毒特异性t细胞反应，而无需血清转化。
We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E and OC43 in 11 SARS-CoV-2 serodiscordant couples in Strasbourg, France, in which 1 partner had evidence of mild coronavirus disease (COVID-19) and in 10 unexposed healthy controls. Patients with confirmed COVID-19 were considered index patients and their partners close contacts. All index patients displayed positive SARS-CoV-2–specific antibody and T-cell responses that lasted up to 102 days after symptom onset. All contacts remained seronegative for SARS-CoV-2; however, 6 reported COVID-19 symptoms within a median of 7 days after their partners, and 4 of those showed a positive SARS-CoV-2–specific T-cell response against 3 or 4 SARS-CoV-2 antigens that lasted up to 93 days after symptom onset. The 11 couples and controls displayed positive T-cell responses against HCoV-229E or HCoV-OC43. These data suggest that exposure to SARS-CoV-2 can induce virus-specific T-cell responses without seroconversion.
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