Effects of somatosensory stimulation on motor function after subacute stroke.
Effects of somatosensory stimulation on motor function after subacute stroke.
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DOI：
10.1177/1545968309349946
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发表时间：
2010-03
影响因子：
4.2
通讯作者：
Cohen LG
中科院分区：
文献类型：
--
作者：
Conforto AB;Ferreiro KN;Tomasi C;dos Santos RL;Moreira VL;Marie SK;Baltieri SC;Scaff M;Cohen LG
以前的工作表明，在亚急性和慢性卒中患者中，单次外周神经感觉刺激（PSS）对麻痹手的运动功能具有潜在的有益作用。研究不同刺激强度在多个阶段（重复PSS [RPSS]）与运动训练配对使用的影响。为了解决这个问题，22例患者在单半球卒中后的第二个月内以平行设计随机分配到运动训练前立即应用2小时RPSS，每周3次，持续1个月。在治疗月结束之前和之后测量Jebsen-Taylor检验（JTT，主要终点测量）、捏力、功能独立性测量（Functional Independence Measure，FSI）和经颅磁刺激的皮质运动兴奋性。在治疗结束后2 ~ 3个月重新评估JTT、JTT评分和捏力。2个RPSS强度组的基线运动功能测试相当。在第1个月时，低强度RPSS组的JTT显著改善，但高强度RPSS组无改善。两组之间的这种差异在2至3个月内缩小。这些结果表明，多次RPSS可以促进亚急性卒中后运动功能的训练效果，这取决于刺激的强度。建议在设计昂贵的、更大的、双盲的、多中心的临床试验之前，需要仔细的剂量-反应研究来优化RPSS刺激的参数。
Previous works showed potentially beneficial effects of a single session of peripheral nerve sensory stimulation (PSS) on motor function of a paretic hand in patients with subacute and chronic stroke. To investigate the influence of the use of different stimulus intensities over multiple sessions (repetitive PSS [RPSS]) paired with motor training. To address this question, 22 patients were randomized within the second month after a single hemispheric stroke in a parallel design to application of 2-hour RPSS at 1 of 2 stimulus intensities immediately preceding motor training, 3 times a week, for 1 month. Jebsen–Taylor test (JTT, primary endpoint measure), pinch force, Functional Independence Measure (FIM), and corticomotor excitability to transcranial magnetic stimulation were measured before and after the end of the treatment month. JTT, FIM scores, and pinch force were reevaluated 2 to 3 months after the end of the treatment. Baseline motor function tests were comparable across the 2 RPSS intensity groups. JTT improved significantly in the lower intensity RPSS group but not in the higher intensity RPSS group at month 1. This difference between the 2 groups reduced by months 2 to 3. These results indicate that multiple sessions of RPSS could facilitate training effects on motor function after subacute stroke depending on the intensity of stimulation. It is proposed that careful dose–response studies are needed to optimize parameters of RPSS stimulation before designing costly, larger, double-blind, multicenter clinical trials.
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影响因子：
8.3
作者：
Celnik, Pablo;Paik, Nam-Jong;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
2.5
作者：
Di Lazzaro, V.;Pilato, F.;Rothwell, J. C.
通讯作者：
Rothwell, J. C.
DOI：
10.1016/j.apmr.2007.08.001
发表时间：
2007-11-01
影响因子：
4.3
作者：
Celnik, Pablo;Hummel, Friedhelm;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
3
作者：
Kaelin-Lang, A;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
4.2
作者：
Klaiput, Akkarapol;Kitisomprayoonkul, Wasuwat
通讯作者：
Kitisomprayoonkul, Wasuwat