Selective expansion of the monocytic lineage directed by bacterial infection.
Selective expansion of the monocytic lineage directed by bacterial infection.
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DOI：
10.4049/jimmunol.0900612
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发表时间：
2009-08-01
期刊：
影响因子：
--
通讯作者：
Pamer EG
中科院分区：
文献类型：
--
作者：
Serbina NV;Hohl TM;Cherny M;Pamer EG
CCR2 介导的 Ly6Chigh 单核细胞的募集对于防御一系列微生物病原体至关重要。尽管我们对单核细胞运输至炎症部位的了解不断增加，但先天免疫炎症如何影响微生物感染期间单核细胞的发育和成熟仍不清楚。在此，我们证明细胞内细菌病原体单核细胞增生李斯特氏菌的感染特异性且选择性地促进单核细胞形成。有毒力的单核细胞增多性李斯特菌的全身感染会诱导骨髓单核细胞前体细胞的显着增殖，并导致骨髓祖细胞的耗竭。单核细胞前体的增殖与全身感染的强度相关，并且不受骨髓中单核细胞密度的影响。虽然成熟单核细胞群从骨髓的早期迁移不需要 MyD88/Trif 介导的信号传导，但单核细胞群的补充取决于 MyD88/Trif。我们的研究表明，TLR 介导的信号在全身细菌感染期间维持单核细胞稳态中发挥着重要作用。
CCR2-mediated recruitment of Ly6Chigh monocytes is essential for defense against a range of microbial pathogens. Although our understanding of monocyte trafficking to inflammatory sites is increasing, how innate immune inflammation influences monocyte development and maturation during microbial infection remains undefined. Herein, we demonstrate that infection with the intracellular bacterial pathogen Listeria monocytogenes specifically and selectively promotes monopoiesis. Systemic infection with virulent L. monocytogenes induces marked proliferation of bone marrow monocyte precursors and results in depletion of myeloid progenitors. Proliferation of monocyte precursors correlates with the intensity of systemic infection and is unaffected by the density of monocytes in the bone marrow. Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, replenishment of monocyte populations depends on MyD88/Trif. Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection.
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影响因子：
30.5
作者：
Sapoznikov, Anita;Pewzner-Jung, Yael;Jung, Steffen
通讯作者：
Jung, Steffen
影响因子：
64.8
作者：
BIELECKI, J;YOUNGMAN, P;PORTNOY, DA
通讯作者：
PORTNOY, DA
影响因子：
64.5
作者：
Adolfsson, J;Månsson, R;Jacobsen, SEW
通讯作者：
Jacobsen, SEW
DOI：
10.1073/pnas.0706963104
发表时间：
2007-12-11
影响因子：
11.1
作者：
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通讯作者：
Bozzoni, I.
影响因子：
32.4
作者：
Serbina, NV;Salazar-Mather, TP;Pamer, EG
通讯作者：
Pamer, EG