Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles.
Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles.
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DOI：
10.1016/j.addr.2011.05.017
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发表时间：
2011-09-10
影响因子：
16.1
通讯作者：
Forrest, M. Laird
中科院分区：
文献类型：
--
作者：
Cai, Shuang;Yang, Qiuhong;Bagby, Taryn R.;Forrest, M. Laird
关键词：
淋巴系统在免疫系统对疾病的识别和反应中起着至关重要的作用，大多数实体癌在血液学传播之前最初通过肿瘤周围的淋巴系统从原发部位扩散。因此，淋巴系统是开发新疫苗、癌症治疗和诊断剂的重要靶点。已经评估了通过皮下、肠和肺途径靶向淋巴系统，并随后用于改善药物分子的淋巴渗透和保留，降低药物相关的全身毒性，并提高难溶性和不稳定药物的生物利用度。淋巴成像是癌症检测和分期的重要工具。新的纳米技术提供了更好的结节疾病的检测和表征，而新的输送设备可以更好地靶向和限制治疗结节空间内的肿瘤，同时保留健康组织。本文综述了淋巴给药和显像领域的最新进展，重点介绍了脂质体和固体脂质纳米粒经皮下、肠和肺途径进入淋巴的研究进展。
The lymphatic system plays a crucial role in the immune system’s recognition and response to disease, and most solid cancers initially spread from the primary site via the tumor’s surrounding lymphatics before hematological dissemination. Hence, the lymphatic system is an important target for developing new vaccines, cancer treatments, and diagnostic agents. Targeting the lymphatic system by subcutaneous, intestinal, and pulmonary routes has been evaluated and subsequently utilized to improve lymphatic penetration and retention of drug molecules, reduce drug-related systemic toxicities, and enhance bioavailability of poorly soluble and unstable drugs. Lymphatic imaging is an essential tool for the detection and staging of cancer. New nano-based technologies offer improved detection and characterization of the nodal diseases, while new delivery devices can better target and confine treatments to tumors within the nodal space while sparing healthy tissues. This manuscript reviews recent advances in the field of lymphatic drug delivery and imaging and focuses specifically on the development ofliposomes and solid lipid nanoparticles for lymphatic introduction via the subcutaneous, intestinal, and pulmonary routes.
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影响因子：
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