Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission.
Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission.
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母亲和婴儿中HIV-1 ENV特异性抗体的FC受体参与预测垂直传播减少。
DOI：
10.3389/fimmu.2022.1051501
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission. HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV. This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity.
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DOI：
10.1016/s1701-2163(15)30515-6
发表时间：
2014-08-01
影响因子：
1.8
作者：
Money, Deborah;Tulloch, Karen;van Schalkwyk, Julie
通讯作者：
van Schalkwyk, Julie
影响因子：
7.3
作者：
Mielke, Dieter;Bandawe, Gama;Williamson, Carolyn
通讯作者：
Williamson, Carolyn
影响因子：
3.7
作者：
Chenine AL;Wieczorek L;Sanders-Buell E;Wesberry M;Towle T;Pillis DM;Molnar S;McLinden R;Edmonds T;Hirsch I;O'Connell R;McCutchan FE;Montefiori DC;Ochsenbauer C;Kappes JC;Kim JH;Polonis VR;Tovanabutra S
通讯作者：
Tovanabutra S
影响因子：
7.3
作者：
Alonso S;Vidal M;Ruiz-Olalla G;González R;Manaca MN;Jairoce C;Vázquez-Santiago M;Balcells R;Vala A;Rupérez M;Cisteró P;Fuente-Soro L;Cova M;Angov E;Nhacolo A;Sevene E;Aponte JJ;Macete E;Aguilar R;Mayor A;Menéndez C;Dobaño C;Moncunill G
通讯作者：
Moncunill G
影响因子：
3.7
作者：
Edmonds TG;Ding H;Yuan X;Wei Q;Smith KS;Conway JA;Wieczorek L;Brown B;Polonis V;West JT;Montefiori DC;Kappes JC;Ochsenbauer C
通讯作者：
Ochsenbauer C