Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique.
Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique.
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莫桑比克HIV感染妇女中抗多种微生物和疫苗抗原抗体的胎盘转移减少。
DOI：
10.3389/fimmu.2021.614246
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发表时间：
2021
影响因子：
7.3
通讯作者：
Moncunill G
中科院分区：
文献类型：
--
作者：
Alonso S;Vidal M;Ruiz-Olalla G;González R;Manaca MN;Jairoce C;Vázquez-Santiago M;Balcells R;Vala A;Rupérez M;Cisteró P;Fuente-Soro L;Cova M;Angov E;Nhacolo A;Sevene E;Aponte JJ;Macete E;Aguilar R;Mayor A;Menéndez C;Dobaño C;Moncunill G
抗体的经胎盘转移对于保护新生儿免受传染病至关重要。我们评估了不同因素（包括胎龄和 HIV 和疟疾等孕产妇感染）对脐带血水平和 IgG 亚类胎盘转移效率的影响。我们通过定量悬浮阵列技术测量了来自莫桑比克南部的 341 对未感染 HIV 和感染 HIV 的母婴对 14 种病原体和疫苗抗原（包括母体免疫目标）的总 IgG 和 IgG 亚类。我们分析了孕产妇艾滋病毒感染、恶性疟原虫暴露、孕产妇变量和妊娠结局与脐带抗体水平和经胎盘转移的关系。我们的结果表明，母源抗体水平是脐带抗体水平的主要决定因素。单变量和多变量分析表明，HIV 主要降低了胎盘转移和脐带中 IgG 和 IgG1 的水平，而且还降低了 IgG2 至所测试抗原的一半。恶性疟原虫暴露和早产与脐带抗体水平和胎盘转移呈负相关，但这与抗原亚类相关。我们的研究结果表明，母体转移抗体较低可能是暴露于艾滋病毒的婴儿感染易感性增加的原因。这可能会影响孕产妇疫苗接种的效果，特别是在撒哈拉以南非洲地区，那里艾滋病毒、疟疾和不利环境因素的流行率很高。
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of IgG subclasses. We measured total IgG and IgG subclasses by quantitative suspension array technology against 14 pathogens and vaccine antigens, including targets of maternal immunization, in 341 delivering HIV-uninfected and HIV-infected mother-infant pairs from southern Mozambique. We analyzed the association of maternal HIV infection, Plasmodium falciparum exposure, maternal variables and pregnancy outcomes on cord antibody levels and transplacental transfer. Our results show that maternal antibody levels were the main determinant of cord antibody levels. Univariable and multivariable analysis showed that HIV reduced the placental transfer and cord levels of IgG and IgG1 principally, but also IgG2 to half of the antigens tested. P. falciparum exposure and prematurity were negatively associated with cord antibody levels and placental transfer, but this was antigen-subclass dependent. Our findings suggest that lower maternally transferred antibodies may underlie increased susceptibility to infections of HIV-exposed infants. This could affect efficacy of maternal vaccination, especially in sub-Saharan Africa, where there is a high prevalence of HIV, malaria and unfavorable environmental factors.
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影响因子：
6.4
作者：
Dangor, Ziyaad;Kwatra, Gaurav;Madhi, Shabir A.
通讯作者：
Madhi, Shabir A.
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