Serum lipids and lipoproteins during continuous ambulatory peritoneal dialysis.

Serum lipids and lipoproteins during continuous ambulatory peritoneal dialysis.
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连续非卧床腹膜透析期间的血清脂质和脂蛋白。

DOI:
10.1111/j.0954-6820.1986.tb02742.x
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发表时间:
1986
影响因子:
--
通讯作者:
Norbeck,HE
Norbeck,HE
中科院分区:
--
文献类型:
--
作者:
Lindholm,B;Norbeck,HE

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本文观察了23例尿毒症患者连续性非卧床腹膜透析(CAPD)治疗最初一年对血脂及脂蛋白的影响。在CAPD开始时,存在尿毒症异常脂蛋白血症的典型脂蛋白异常。在CAPD的头几个月,这些异常加重。极低密度脂蛋白(VLDL)-胆固醇(CHOL)、低密度脂蛋白(LDL)-CHOL、血清CHOL和血清甘油三酯(TG)浓度显著升高。然而,CAPD一年后,只有VLDL‐CHOL和血清CHOL水平仍显著高于基线值。VLDL‐TG、VLDL‐CHOL和血清TG以及这些变量在研究期间的变化与透析液中的葡萄糖量相关。我们得出结论,CAPD期间葡萄糖的持续腹膜吸收(100 - 200 g/24 h)有助于血清脂质和脂蛋白的潜在致动脉粥样硬化变化。然而,一些变化是暂时的,表明对腹膜葡萄糖负荷的适应。
The effects of continouos ambulatory peritoneal dialysis (CAPD) on serum lipids and lipoproteins over the initial year of therapy were studied in 23 uremic patients. Lipoprotein abnormalities typical for the uremic dyslipoproteinemia were present at the start of CAPD. During the first months of CAPD these abnormalities were accentuated. The concentrations of very low density lipoprotein (VLDL)‐cholesterol (CHOL), low density lipoprotein (LDL)‐CHOL, serum CHOL and serum triglycerides (TG) increased significantly. However, after one year of CAPD only the VLDL‐CHOL and serum CHOL levels remained significantly higher than the baseline values. VLDL‐TG, VLDL‐CHOL and serum TG, and the changes of these variables over the study period, correlated with the amount of glucose in the dialysates. We conclude that the continuous peritoneal absorption of glucose (100‐200 g/24 h) during CAPD contributes to potentially atherogenic changes in serum lipids and lipoproteins. However, some of the changes are transitory, indicating an adaptation to the peritoneal glucose load.
DOI: --
发表时间: 2009
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