Early ethanol consumption predicts relapse-like behavior in adolescent male rats.
Early ethanol consumption predicts relapse-like behavior in adolescent male rats.
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早期乙醇消耗预示着青春期雄性大鼠的复发样行为。
DOI：
10.1111/j.1530-0277.2008.00631.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kuhn,CynthiaM
中科院分区：
文献类型：
--
作者：
Schramm-Sapyta,NicoleL;Kingsley,MeganA;Rezvani,AmirH;Propst,Kiayia;Swartzwelder,HScott;Kuhn,CynthiaM
背景：随着时间的推移，酒精滥用障碍会随着重复饮用乙醇而出现，但并不是所有的乙醇饮用者都会出现这些障碍。有一些预先存在的特征表明哪些饮酒者最有可能滥用酒精。青春期、寻求新奇和高度应激反应是最脆弱的个体的特征。此外，一个人对他或她第一次接触毒品的反应会影响未来的消费。我们评估了一系列的行为和激素特征在青春期（28天）雄性大鼠暴露于乙醇之前，然后确定哪些大鼠是最容易高水平的酒精drinking.Methods：该评估包括措施的焦虑（高架加迷宫），对新奇事物的反应（开放领域的运动，新的物体探索），和循环皮质酮水平后，轻度限制和高架加迷宫任务。在该试验组之后，将大鼠每晚（下午5点至上午9点）置于Lickometer笼中以评价液体消耗。首先使大鼠习惯于在舔舐瓶中装有水的笼子，然后给予10%（v/v）乙醇作为唯一可用的流体3晚。在这种强制乙醇暴露后，大鼠被允许在8%的乙醇和水之间选择连续10个晚上。经过2个晚上的禁欲，大鼠再次被放置在lickometer笼，并给予8%的乙醇和水之间的选择，以评估乙醇消耗响应酒精剥夺，复发样behaviors.Results的措施：乙醇消耗量的第三天强迫消费与乙醇消耗量的第8天至第10天的选择阶段，这反过来又是显着相关的复发样消费。对乙醇的偏好也与早期消费显着相关。新的对象探索，开放领域的活动，开放的手臂时间在高架十字迷宫，初始水的消耗量，和循环皮质酮水平并没有显着预测剥夺刺激consumption.Conclusions：这些结果表明，消费在早期暴露于乙醇建立了一个模式，导致发展中国家增加酒精消费和偏好的青春期雄性大鼠。此外，它们代表了一种动物模型，该模型充分描述了观察结果，即在早期暴露期间消耗大量乙醇的人最有可能重复重度饮酒行为。此外，早期消费与寻求新奇，焦虑和压力激素水平不同，这些激素水平也被认为是导致酗酒的原因。
Background:Alcohol abuse disorders emerge over time with repeated consumption of ethanol, but not all ethanol drinkers develop these disorders. There are pre‐existing characteristics that indicate which drinkers are most likely to abuse alcohol. Adolescence, novelty seeking, and high stress reactivity are among the characteristics of the most vulnerable individuals. In addition, an individual’s response to his or her first exposure to the drug influences future consumption. We assessed an array of behavioral and hormonal characteristics in adolescent (28‐day‐old) male rats before exposure to ethanol, and then determined which rats were most prone to high levels of alcohol drinking.Methods:The assessments consisted of measures of anxiety (elevated plus maze), response to novelty (open field locomotion, novel object exploration), and circulating corticosterone levels after mild restraint and after the elevated plus maze task. After this test battery, the rats were placed in lickometer cages nightly (5pmto 9am) for evaluation of fluid consumption. Rats were first habituated to the cages with water in the lickometer bottles, and then given 10% (v/v) ethanol for 3 nights as the only available fluid. After this forced ethanol exposure, the rats were allowed to choose between 8% ethanol and water for 10 consecutive nights. After 2 nights of abstinence, the rats were again placed in the lickometer cages and given a choice between 8% ethanol and water to assess ethanol consumption in response to alcohol deprivation, a measure of relapse‐like behavior.Results:Ethanol consumption on the third day of forced consumption was significantly correlated with ethanol consumption on days 8 to 10 of the choice phase, which in turn was significantly correlated to relapse‐like consumption. Preference for ethanol was also significantly correlated with early consumption. Novel object exploration, open field activity, open arm time in the elevated plus maze, initial water consumption, and circulating corticosterone levels did not significantly predict deprivation‐stimulated consumption.Conclusions:These results suggest that consumption during early exposure to ethanol establishes a pattern leading to development of increased alcohol consumption and preference in adolescent male rats. In addition, they represent an animal model of the well‐described observation that humans who consume large quantities of ethanol during early exposure are the most likely to repeat heave drinking behavior. Furthermore, early consumption is distinct from novelty seeking, anxiety, and stress hormone levels which are also thought to contribute to vulnerability to alcoholism.
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DOI：
--
发表时间：
1995
期刊：
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
影响因子：
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作者：
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影响因子：
3.4
作者：
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BRITTON, KT
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DOI：
10.15288/jsa.2002.63.91
发表时间：
2002
期刊：
Journal of studies on alcohol
影响因子：
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作者：
S. Cailhol;P. Mormède
通讯作者：
P. Mormède
DOI：
10.1111/j.1530-0277.2002.tb02448.x
发表时间：
2002-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
G. Valdez;A. Roberts;Karen Chan;H. Davis;M. Brennan;E. Zorrilla;G. Koob
通讯作者：
G. Valdez;A. Roberts;Karen Chan;H. Davis;M. Brennan;E. Zorrilla;G. Koob
基因-压力-行为相互作用如何促进青少年饮酒：酒前稳态负荷和儿童行为障碍的作用
影响因子：
3.6
作者：
U. Zimmermann;Dorothea Blomeyer;M. Laucht;K. Mann
通讯作者：
K. Mann