Sex differences in ethanol-related behaviors in genetically defined murine stocks.

Sex differences in ethanol-related behaviors in genetically defined murine stocks.
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基因定义的小鼠种群中乙醇相关行为的性别差异。

DOI:
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发表时间:
1995
期刊:
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
影响因子:
--
通讯作者:
K. Whitfield
K. Whitfield
中科院分区:
--
文献类型:
--
作者:
B. Jones;K. Whitfield

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在过去的30年里,我们对人类过度饮酒的病因和后果的理解有了一些重要的发展。迄今为止最重要的发现之一可能是,人类对酒精的胃口和开始酗酒的年龄存在很大的个体差异。我们在至少两种不同的酒精类型中发现了这一发现,每种类型都有自己的遗传影响估计。我们也逐渐认识到,在问题饮酒的病因学和长期饮酒的后果方面,男女之间存在重要差异。在本章中,应用基因定义动物模型的优点和局限性,主要是选定的小鼠系和近交系,通过文献中的例子进行评估。
Over the past 30 years, there have been a number of important developments in our understanding of the etiology and consequences of excessive drinking among humans. Probably one of the most important findings to date is that there are large individual differences among humans in appetite for alcohol and age of onset of problem drinking. We recognize this finding in at least two different alcoholic types, each with its own estimate of genetic influence. We have also come to realize that there are important differences between men and women, both in etiology of problem drinking and in the consequences of chronic alcohol use. In this chapter, the advantages and limitations of applying genetically defined animal models, primarily, selected lines and inbred strains of mice, are evaluated with examples from the literature.
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