Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.
Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.
复制标题
慢性左皮质下中风伴失语后的远端皮质萎缩和语言结果。
DOI：
10.3389/fnins.2022.853169
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Xing, Shihui
中科院分区：
文献类型：
--
作者：
Tang, Huijia;Fan, Shuhan;Niu, Xingyang;Li, Zhuhao;Xiao, Peiyi;Zeng, Jinsheng;Xing, Shihui
Subcortical stroke can cause a variety of language deficits. However, the neural mechanisms underlying subcortical aphasia after stroke remain incompletely elucidated. We aimed to determine the effects of distant cortical structures on aphasia outcomes and examine the correlation of cortical thickness measures with connecting tracts integrity after chronic left subcortical stroke. Thirty-two patients and 30 healthy control subjects underwent MRI scanning and language assessment with the Western Aphasia Battery-Revised (WAB-R) subtests. Among patients, the cortical thickness in brain regions that related to language performance were assessed by the FreeSurfer software. Fiber tracts connecting the identified cortical regions to stroke lesions were reconstructed to determine its correlations with the cortical thickness measures across individual patient. Cortical thickness in different parts of the left fronto-temporo-parietal (FTP) regions were positively related to auditory-verbal comprehension, spontaneous speech and naming/word finding abilities when controlling for key demographic variables and lesion size. Cortical thickness decline in the identified cortical regions was positively correlated with integrity loss of fiber tracts connected to stroke lesions. Additionally, no significant difference in cortical thickness was found across the left hemisphere between the subgroup of patients with hypoperfusion (HP) and those without HP at stroke onset. These findings suggest that remote cortical atrophy independently predicts language outcomes in patients with chronic left subcortical stroke and aphasia and that cortical thinning in these regions might relate to integrity loss of fiber tracts connected to stroke lesions.
登录
查看更多内容
影响因子：
5.3
作者：
Awad, Malaka;Warren, Jane E.;Wise, Richard J. S.
通讯作者：
Wise, Richard J. S.
影响因子：
4.4
作者：
Brodtmann, Amy;Pardoe, Heath;Cumming, Toby
通讯作者：
Cumming, Toby
影响因子：
9.9
作者：
Duering, Marco;Righart, Ruthger;Dichgans, Martin
通讯作者：
Dichgans, Martin
影响因子：
11
作者：
Hervé, D;Molko, N;Chabriat, H
通讯作者：
Chabriat, H
影响因子：
6.3
作者：
Cheng, Bastian;Schulz, Robert;Thomalla, Goetz
通讯作者：
Thomalla, Goetz