Motor Control and Sensory Feedback Enhance Prosthesis Embodiment and Reduce Phantom Pain After Long-Term Hand Amputation.
Motor Control and Sensory Feedback Enhance Prosthesis Embodiment and Reduce Phantom Pain After Long-Term Hand Amputation.
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DOI：
10.3389/fnhum.2018.00352
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发表时间：
2018
影响因子：
2.9
通讯作者：
Clark GA
中科院分区：
文献类型：
--
作者：
Page DM;George JA;Kluger DT;Duncan C;Wendelken S;Davis T;Hutchinson DT;Clark GA
我们对一名长期经桡动脉截肢患者的假肢实施情况和与运动控制和假手感觉反馈相关的幻痛减少进行了量化。将微电极阵列植入残余的正中和尺臂神经中，并将肌内肌电图记录引线植入残余肢体的肌肉中，以实现感觉反馈和运动控制。使用客观测量（本体感觉漂移）和主观测量（调查答案）来评估假体实施例。对于这两种测量，在假肢的开环运动控制（即，没有感觉反馈）、假肢的开环感觉（即，没有运动控制）和假肢的闭环控制（即，有感觉反馈的运动控制）之后，物理假肢的体现程度很高。在包括开环神经微刺激、开环假体运动控制或闭环假体运动控制的实验之后，报告的幻痛也有统计学上的显着减少。相对于开环感觉条件或开环运动条件，闭环条件在幻痛减轻或假体实施方面没有提供额外的显着改进。这项研究代表了第一份针对人类截肢者在各种假肢使用案例中减少幻痛和实施假肢的长期（14 个月）系统报告。
We quantified prosthesis embodiment and phantom pain reduction associated with motor control and sensory feedback from a prosthetic hand in one human with a long-term transradial amputation. Microelectrode arrays were implanted in the residual median and ulnar arm nerves and intramuscular electromyography recording leads were implanted in residual limb muscles to enable sensory feedback and motor control. Objective measures (proprioceptive drift) and subjective measures (survey answers) were used to assess prosthesis embodiment. For both measures, there was a significant level of embodiment of the physical prosthetic limb after open-loop motor control of the prosthesis (i.e., without sensory feedback), open-loop sensation from the prosthesis (i.e., without motor control), and closed-loop control of the prosthesis (i.e., motor control with sensory feedback). There was also a statistically significant reduction in reported phantom pain after experimental sessions that included open-loop nerve microstimulation, open-loop prosthesis motor control, or closed-loop prosthesis motor control. The closed-loop condition provided no additional significant improvements in phantom pain reduction or prosthesis embodiment relative to the open-loop sensory condition or the open-loop motor condition. This study represents the first long-term (14-month), systematic report of phantom pain reduction and prosthesis embodiment in a human amputee across a variety of prosthesis use cases.
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影响因子：
17.1
作者：
Graczyk EL;Schiefer MA;Saal HP;Delhaye BP;Bensmaia SJ;Tyler DJ
通讯作者：
Tyler DJ
影响因子：
1.5
作者：
Biddiss, Elaine A.;Chau, Tom T.
通讯作者：
Chau, Tom T.
影响因子：
2.5
作者：
Dhillon, GS;Krüger, TB;Horch, KW
通讯作者：
Horch, KW
影响因子：
4
作者：
Davis, T. S.;Wark, H. A. C.;Greger, B.
通讯作者：
Greger, B.
影响因子：
3.7
作者：
Engdahl SM;Chestek CA;Kelly B;Davis A;Gates DH
通讯作者：
Gates DH