Repeated inversions within a pannier intron drive diversification of intraspecific colour patterns of ladybird beetles.
Repeated inversions within a pannier intron drive diversification of intraspecific colour patterns of ladybird beetles.
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DOI：
10.1038/s41467-018-06116-1
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发表时间：
2018-09-21
影响因子：
16.6
通讯作者：
Niimi T
中科院分区：
文献类型：
--
作者：
Ando T;Matsuda T;Goto K;Hara K;Ito A;Hirata J;Yatomi J;Kajitani R;Okuno M;Yamaguchi K;Kobayashi M;Takano T;Minakuchi Y;Seki M;Suzuki Y;Yano K;Itoh T;Shigenobu S;Toyoda A;Niimi T
遗传信息如何被修改以产生物种内的表型变异是进化生物学的中心问题之一。在这里，我们专注于引人注目的种内多样性的>200 aposematic鞘翅（前翅）颜色模式的多色亚洲瓢虫，异色瓢虫，这是由一个紧密连锁的遗传位点h。我们的功能丧失分析、遗传关联研究、从头基因组组装和基因表达数据显示，加塔转录因子基因pannier是位于h位点的主要调控基因，并表明pannier的重复倒位和顺式调控修饰导致了H.异色。此外，我们发现pannier的颜色图案功能在七星瓢虫中是保守的，这表明H。异色瓢虫非同寻常的种内变异可能源于瓢虫中保守的鞘翅颜色图案机制的古老修改。异色瓢虫（Harmonia axyridis）具有显著的表型多样性，有超过200种颜色模式。在这里，Ando等人表明，这种模式是由转录因子基因pannier调节的，并通过pannier的重复倒位和顺式调节修饰而多样化。
How genetic information is modified to generate phenotypic variation within a species is one of the central questions in evolutionary biology. Here we focus on the striking intraspecific diversity of >200 aposematic elytral (forewing) colour patterns of the multicoloured Asian ladybird beetle, Harmonia axyridis, which is regulated by a tightly linked genetic locus h. Our loss-of-function analyses, genetic association studies, de novo genome assemblies, and gene expression data reveal that the GATA transcription factor gene pannier is the major regulatory gene located at the h locus, and suggest that repeated inversions and cis-regulatory modifications at pannier led to the expansion of colour pattern variation in H. axyridis. Moreover, we show that the colour-patterning function of pannier is conserved in the seven-spotted ladybird beetle, Coccinella septempunctata, suggesting that H. axyridis’ extraordinary intraspecific variation may have arisen from ancient modifications in conserved elytral colour-patterning mechanisms in ladybird beetles. The harlequin ladybird beetle, Harmonia axyridis, has remarkable phenotypic diversity, with over 200 colour patterns. Here, Ando et al. show that this patterning is regulated by the transcription factor gene pannier and has diversified by repeated inversions and cis-regulatory modifications of pannier.
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影响因子：
64.8
作者：
Joron, Mathieu;Frezal, Lise;Jones, Robert T.;Chamberlain, Nicola L.;Lee, Siu F.;Haag, Christoph R.;Whibley, Annabel;Becuwe, Michel;Baxter, Simon W.;Ferguson, Laura;Wilkinson, Paul A.;Salazar, Camilo;Davidson, Claire;Clark, Richard;Quail, Michael A.;Beasley, Helen;Glithero, Rebecca;Lloyd, Christine;Sims, Sarah;Jones, Matthew C.;Rogers, Jane;Jiggins, Chris D.;Ffrench-Constant, Richard H.
通讯作者：
Ffrench-Constant, Richard H.
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
DOI：
10.1016/j.cub.2018.08.023
发表时间：
2018-10-22
期刊：
Current biology : CB
影响因子：
--
作者：
Gautier M;Yamaguchi J;Foucaud J;Loiseau A;Ausset A;Facon B;Gschloessl B;Lagnel J;Loire E;Parrinello H;Severac D;Lopez-Roques C;Donnadieu C;Manno M;Berges H;Gharbi K;Lawson-Handley L;Zang LS;Vogel H;Estoup A;Prud'homme B
通讯作者：
Prud'homme B
影响因子：
7
作者：
Kajitani R;Toshimoto K;Noguchi H;Toyoda A;Ogura Y;Okuno M;Yabana M;Harada M;Nagayasu E;Maruyama H;Kohara Y;Fujiyama A;Hayashi T;Itoh T
通讯作者：
Itoh T
影响因子：
1.8
作者：
Daloze, Desire;Braekman, Jean-Claude;Pasteels, Jacques M.
通讯作者：
Pasteels, Jacques M.