Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry.
Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry.
复制标题
DOI：
10.1038/nature10341
复制
发表时间：
2011-08-14
期刊：
影响因子：
64.8
通讯作者：
Ffrench-Constant, Richard H.
中科院分区：
文献类型：
--
作者：
Joron, Mathieu;Frezal, Lise;Jones, Robert T.;Chamberlain, Nicola L.;Lee, Siu F.;Haag, Christoph R.;Whibley, Annabel;Becuwe, Michel;Baxter, Simon W.;Ferguson, Laura;Wilkinson, Paul A.;Salazar, Camilo;Davidson, Claire;Clark, Richard;Quail, Michael A.;Beasley, Helen;Glithero, Rebecca;Lloyd, Christine;Sims, Sarah;Jones, Matthew C.;Rogers, Jane;Jiggins, Chris D.;Ffrench-Constant, Richard H.
超基因是紧密的基因座簇，促进适应性变异的共分离，对复杂的适应性表型提供综合控制。多态性超基因中，特定的性状组合在一个单一群体内得以维持，最初是在报春花属和荞麦属的“柱头”和“花药”花型中被描述的，但在昆虫拟态和蜗牛形态中也发现了经典的例子。理解产生这些协同适应的基因集的进化机制，以及限制产生不适应的重组形式的模式，仍然是一个重大挑战。在此我们表明，多态性拟态蝴蝶Heliconius numata的个体翅纹形态与超基因位点P处的不同基因组重排相关。这些重排加强了至少两个已知在近缘物种中会重组的颜色模式基因座之间的遗传连锁，在跨越一个包含至少18个基因的400千碱基区间的实验杂交中观察到重组被完全抑制。在自然种群中，在整个P区域观察到显著的连锁不平衡（LD）模式。由此产生的不同单倍型分支和倒位断点被发现与翅纹形态完全相关。我们的结果表明，已知翅纹基因座上的等位基因组合在P位点的多态性重排中被锁定在一起，形成一个超基因，作为在同域分布中发现的复杂适应性表型之间的一个简单开关。这些发现凸显了基因组重排如何通过局部限制重组和基因流，在涉及多个协同作用的基因的适应性表型的共存中发挥核心作用。
Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation, providing integrated control of complex adaptive phenotypes. Polymorphic supergenes, in which specific combinations of traits are maintained within a single population, were first described for ‘pin’ and ‘thrum’ floral types in Primula and Fagopyrum, but classic examples are also found in insect mimicry and snail morphology. Understanding the evolutionary mechanisms that generate these co-adapted gene sets, as well as the mode of limiting the production of unfit recombinant forms, remains a substantial challenge. Here we show that individual wing-pattern morphs in the polymorphic mimetic butterfly Heliconius numata are associated with different genomic rearrangements at the supergene locus P. These rearrangements tighten the genetic linkage between at least two colour-pattern loci that are known to recombine in closely related species, with complete suppression of recombination being observed in experimental crosses across a 400-kilobase interval containing at least 18 genes. In natural populations, notable patterns of linkage disequilibrium (LD) are observed across the entire P region. The resulting divergent haplotype clades and inversion breakpoints are found in complete association with wing-pattern morphs. Our results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the Plocus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow.
登录
查看更多内容
影响因子：
4.5
作者：
Counterman BA;Araujo-Perez F;Hines HM;Baxter SW;Morrison CM;Lindstrom DP;Papa R;Ferguson L;Joron M;Ffrench-Constant RH;Smith CP;Nielsen DM;Chen R;Jiggins CD;Reed RD;Halder G;Mallet J;McMillan WO
通讯作者：
McMillan WO
影响因子：
4.5
作者：
Baxter SW;Nadeau NJ;Maroja LS;Wilkinson P;Counterman BA;Dawson A;Beltran M;Perez-Espona S;Chamberlain N;Ferguson L;Clark R;Davidson C;Glithero R;Mallet J;McMillan WO;Kronforst M;Joron M;Ffrench-Constant RH;Jiggins CD
通讯作者：
Jiggins CD
影响因子：
9.8
作者：
Joron M;Papa R;Beltrán M;Chamberlain N;Mavárez J;Baxter S;Abanto M;Bermingham E;Humphray SJ;Rogers J;Beasley H;Barlow K;ffrench-Constant RH;Mallet J;McMillan WO;Jiggins CD
通讯作者：
Jiggins CD
影响因子：
5.8
作者：
Mayor, C;Brudno, M;Dubchak, I
通讯作者：
Dubchak, I
影响因子：
3.3
作者：
MATHER, K
通讯作者：
MATHER, K